MAP4K5 and IFT88

		MAP4K5	IFT88
Description		mitogen-activated protein kinase kinase kinase kinase 5	intraflagellar transport 88
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium	Manchette Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Intraciliary Transport Particle B Motile Cilium Centriolar Satellite Ciliary Basal Body Sperm Flagellum Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Tip Ciliary Base Non-motile Cilium Sperm Head-tail Coupling Apparatus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Kinesin Binding
	Biological Process	MAPK Cascade Intracellular Signal Transduction	Kidney Development Cell Projection Organization Response To Silicon Dioxide Intraciliary Anterograde Transport Intraciliary Transport Positive Regulation Of Cilium Assembly Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly
Pathways			Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)	Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		14 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK IFT88 NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440	20 interacting genes: ALDH8A1 CACNA1C CAPN7 CCDC120 DSCAM EEF2KMT EML2 FBXO7 HUNK ITPKB MAP4K5 MSRB1 PCOTH PDX1 PRRC2A RPGR SAP18 SMARCE1 TRIM24 VHL
Entrez ID		11183	8100
HPRD ID		05374	09000
Ensembl ID		ENSG00000012983	ENSG00000032742
Uniprot IDs		B3KWC4 Q9Y4K4	A0A140VJL7 B3KX42 Q13099
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Protein-containing Complex Regulation Of Dendrite Development Helper T Cell Diapedesis Regulation Of Cellular Component Organization Ephrin Receptor Binding Response To External Biotic Stimulus Cerebellar Neuron Development Regulation Of Immune Response Regulation Of Mononuclear Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Plasma Membrane Bounded Cell Projection Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Regulation Of T Cell Migration Regulation Of Metabolic Process Enzyme Binding Diapedesis Regulation Of Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neuron Projection Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Regulation Of Lymphocyte Migration Negative Regulation Of Immune Response Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Transforming Growth Factor Beta Regulation Of Leukocyte Migration Protein Domain Specific Binding Leukocyte Migration Regulation Of Anatomical Structure Morphogenesis Immune System Process Signaling Adaptor Activity Postsynaptic Specialization Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Cytosol Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Nitric Oxide
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