MAP4K5 and SETDB1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAP4K5	SETDB1
Description		mitogen-activated protein kinase kinase kinase kinase 5	SET domain bifurcated histone lysine methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9 Trimethyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	MAPK Cascade Intracellular Signal Transduction	Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Methylation Heterochromatin Organization Transposable Element Silencing By Heterochromatin Formation
Pathways			PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)	Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Chronic kidney disease ( 20383146) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 32041948) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785) Neurological blood protein biomarker levels ( 31320639) Nevus count or cutaneous melanoma ( 30429480)
Interacting Genes		14 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK IFT88 NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440	111 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 BTG3 CBX8 CCDC106 CDK4 CDKN1A CFAP68 CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4C16 HDAC1 HDAC2 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TSPAN15 TTR TXNDC9 UBE2I ULK2 USP11 VHL VIM ZFP64 ZNF24
Entrez ID		11183	9869
HPRD ID		05374	06828
Ensembl ID		ENSG00000012983	ENSG00000143379
Uniprot IDs		B3KWC4 Q9Y4K4	A0A8I5KT93 Q15047 X6R732
PDB IDs			3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI 7C9N 7CAJ 7CD9 7CJT 8G5E 8IYA 8UWP 9CUW 9CUX
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Protein-containing Complex Regulation Of Dendrite Development Helper T Cell Diapedesis Regulation Of Cellular Component Organization Ephrin Receptor Binding Response To External Biotic Stimulus Cerebellar Neuron Development Regulation Of Immune Response Regulation Of Mononuclear Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Plasma Membrane Bounded Cell Projection Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Regulation Of T Cell Migration Regulation Of Metabolic Process Enzyme Binding Diapedesis Regulation Of Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neuron Projection Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Regulation Of Lymphocyte Migration Negative Regulation Of Immune Response Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Transforming Growth Factor Beta Regulation Of Leukocyte Migration Protein Domain Specific Binding Leukocyte Migration Regulation Of Anatomical Structure Morphogenesis Immune System Process Signaling Adaptor Activity Postsynaptic Specialization Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Cytosol Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Nitric Oxide	Transcription Corepressor Activity Nucleus Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic SUMO Transferase Activity Regulation Of RNA Metabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Coregulator Activity Constitutive Heterochromatin Formation Cytoplasm MRF Binding Chromatin Binding Transcription Regulator Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Ubiquitin Protein Ligase Binding Sin3-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Protein Sumoylation Nuclear Matrix Nuclear Body RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Krueppel-associated Box Domain Binding Enzyme Binding
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