CLU and BTG3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CLU	BTG3
Description		clusterin	BTG anti-proliferation factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Platelet Alpha Granule Lumen Cytoplasmic Vesicle Mitochondrial Membrane Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen	Nucleus Cytoplasm
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein Heterodimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Protein Sequestering Activity Protein Carrier Chaperone	Protein Binding
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Immune Complex Clearance Protein Folding Lipid Metabolic Process Apoptotic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Complement Activation Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Amyloid-beta Clearance Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle
Pathways		Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)
Interacting Genes		68 interacting genes: ADGRF4 APP BAG6 BTG3 C7 C8B C9 CBR3 CBY1 CD209 CLUAP1 CYP2E1 DISC1 DLG4 DSCAM DSCR9 DUSP13B DYRK1A ELN EPPIN ETS2 FOS GEMIN7 GRB2 HSPA13 HSPD1 HUNK IL24 KATNA1 KEAP1 KLF11 KNSTRN KRT12 LCOR LEP LEPR LIG4 LRP1 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 NAT2 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 RSPH1 SHANK3 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT	76 interacting genes: ADNP2 AFF4 AGAP2 AHCYL1 AIP ATXN1 BANP CACNA1A CCDC13 CCT7 CLTC CLU CNOT7 CNOT8 CNTN4 COPS5 CREBZF CRYL1 DCLK2 DDX18 DIS3L DMAP1 DNAJC14 DNAJC7 DYNC1H1 EIF3C EIF3F EPRS1 GLUL HECTD2 HECTD4 HIVEP2 HSP90AA1 HSP90AB1 KCNQ2 KDM3A KIF3A MAPK8IP3 MORF4L1 MRPL38 MTM1 MYCBP2 NISCH NRBP1 OGT OSBPL8 OTOF PAK1 PAX6 PLA2G3 PLEKHB1 PPP2R5E PPP3CA PRKAR1A QARS1 RANBP9 RBL2 RNF10 RSPH1 SEC23IP SETDB1 SMG5 SPARCL1 SRPK2 SYNE1 TAF1 TAF6 TRIM32 TSC2 TSPAN7 USP8 WAPL WDFY3 XPC ZNF532 ZNF592
Entrez ID		1191	10950
HPRD ID		01706	10415
Ensembl ID		ENSG00000120885	ENSG00000154640
Uniprot IDs		P10909	Q14201 Q6IAU3
PDB IDs		7ZET 7ZEU
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Neuron Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Receptor Complex Cell Activation Positive Regulation Of Protein Catabolic Process Membrane Attack Complex Other Organism Cell Membrane Regulation Of Proteolysis Cargo Receptor Activity Response To Stress Regulation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signal Transduction Dendritic Spine Organization System Development Endocytosis Clathrin-coated Pit Memory Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Development High-density Lipoprotein Particle Binding Anatomical Structure Morphogenesis Protein-containing Complex Binding Regulation Of Cell Projection Organization Intracellular Signal Transduction Complement Activation, GZMK Pathway Nervous System Development Cellular Response To Growth Factor Stimulus Reelin Receptor Activity Positive Regulation Of Proteolysis Transmembrane Transporter Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Cell Activation Immune Effector Process Immune System Process Postsynapse Organization Regulation Of Immune System Process Regulation Of Developmental Process Complement Activation, Alternative Pathway Terpenoid Metabolic Process Cellular Response To Oxygen-containing Compound Cognition	Cytosol Cytoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Establishment Of Localization In Cell Regulation Of Macromolecule Biosynthetic Process Eukaryotic Translation Initiation Factor 3 Complex Organelle Organization Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process RNA Binding Cytoskeleton Organization Chaperone-mediated Protein Complex Assembly Protein Localization To Organelle Translation Initiation Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Unfolded Protein Binding Regulation Of Gene Expression Translation Intracellular Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Intracellular Protein Localization Disordered Domain Specific Binding Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Telomerase Holoenzyme Complex Assembly Negative Regulation Of Catabolic Process CCR4-NOT Core Complex Chromatin Organization 3'-5'-RNA Exonuclease Activity Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding ATP-dependent Protein Folding Chaperone
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