CLU and C8B

Number of citations of the paper that reports this interaction (PubMedID 8345200)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CLU	C8B
Description		clusterin	complement C8 beta chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Platelet Alpha Granule Lumen Cytoplasmic Vesicle Mitochondrial Membrane Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex Extracellular Vesicle
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein Heterodimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Protein Sequestering Activity Protein Carrier Chaperone	Protein-containing Complex Binding
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Immune Complex Clearance Protein Folding Lipid Metabolic Process Apoptotic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Complement Activation Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Amyloid-beta Clearance Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways		Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc Copper Zinc acetate
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		68 interacting genes: ADGRF4 APP BAG6 BTG3 C7 C8B C9 CBR3 CBY1 CD209 CLUAP1 CYP2E1 DISC1 DLG4 DSCAM DSCR9 DUSP13B DYRK1A ELN EPPIN ETS2 FOS GEMIN7 GRB2 HSPA13 HSPD1 HUNK IL24 KATNA1 KEAP1 KLF11 KNSTRN KRT12 LCOR LEP LEPR LIG4 LRP1 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 NAT2 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 RSPH1 SHANK3 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT	3 interacting genes: C5 C8A CLU
Entrez ID		1191	732
HPRD ID		01706	00410
Ensembl ID		ENSG00000120885	ENSG00000021852
Uniprot IDs		P10909	A0A8Q3WL56 B7Z550 B7Z555 P07358
PDB IDs		7ZET 7ZEU	3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Neuron Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Receptor Complex Cell Activation Positive Regulation Of Protein Catabolic Process Membrane Attack Complex Other Organism Cell Membrane Regulation Of Proteolysis Cargo Receptor Activity Response To Stress Regulation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signal Transduction Dendritic Spine Organization System Development Endocytosis Clathrin-coated Pit Memory Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Development High-density Lipoprotein Particle Binding Anatomical Structure Morphogenesis Protein-containing Complex Binding Regulation Of Cell Projection Organization Intracellular Signal Transduction Complement Activation, GZMK Pathway Nervous System Development Cellular Response To Growth Factor Stimulus Reelin Receptor Activity Positive Regulation Of Proteolysis Transmembrane Transporter Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Cell Activation Immune Effector Process Immune System Process Postsynapse Organization Regulation Of Immune System Process Regulation Of Developmental Process Complement Activation, Alternative Pathway Terpenoid Metabolic Process Cellular Response To Oxygen-containing Compound Cognition	Complement Activation, Classical Pathway Complement Activation Other Organism Cell Membrane Membrane Attack Complex Transmembrane Transporter Complex Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Humoral Immune Response Immune Effector Process Activation Of Immune Response Innate Immune Response Positive Regulation Of Immune Response Defense Response To Other Organism Defense Response To Symbiont Regulation Of Immune Response Receptor Ligand Activity Killing Of Cells Of Another Organism Blood Microparticle Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Positive Regulation Of Immune System Process Response To Other Organism Immune Response Cell Killing Positive Regulation Of Neurofibrillary Tangle Assembly Response To External Biotic Stimulus Defense Response Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Extracellular Space Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Regulation Of Immune System Process Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Macrophage Chemotaxis Complement Binding Protein Import Protein-containing Complex Binding Immune System Process Spherical High-density Lipoprotein Particle Signaling Receptor Binding Microglial Cell Proliferation Extracellular Exosome Protein Carrier Chaperone Extracellular Region
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