FRA10AC1 and VPS29

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FRA10AC1	VPS29
Description		FRA10A associated CGG repeat 1	VPS29 retromer complex component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Membrane Retromer Complex Retromer, Cargo-selective Complex
	Molecular Function	Protein Binding Phosphatase Activity	Protein Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome	Intracellular Protein Transport Regulation Of Autophagy Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi
Pathways			WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 26252872 29274321) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: ADPRS C7orf25 CHERP CWC27 EEF1D GATD3 GDPD2 GLRX3 HABP4 IK KASH5 MAP3K12 MFAP1 MOB2 NKAP PLPPR4 PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830	7 interacting genes: APP FRA10AC1 RGS2 SH2B3 SNCA TMCO4 VPS35
Entrez ID		118924	51699
HPRD ID		12319	09499
Ensembl ID		ENSG00000148690	ENSG00000111237
Uniprot IDs		Q70Z53	A0A384MR19 F8VXU5 Q9UBQ0
PDB IDs			1W24 2R17 5GTU 5OSH 5OSI 5WYH 6XS5 6XS7 6XS9 6XSA 7BLN 8ESE 8P0V 8P0X 8R02 8R0J 8RKS 8SYM 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing U2-type Precatalytic Spliceosome MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Nuclear Speck Spliceosomal Complex Nucleic Acid Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Cajal Body Nucleobase-containing Compound Metabolic Process Catalytic Step 2 Spliceosome U2-type Spliceosomal Complex Glycerophosphoinositol Inositolphosphodiesterase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Nucleus Nucleic Acid Binding	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Dendritic Spine Maintenance Regulation Of Synapse Assembly Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Cellular Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Amyloid Fibril Formation Microglial Cell Activation Presynapse Response To Copper Ion Postsynapse Leukocyte Activation Involved In Inflammatory Response Regulation Of Cell Junction Assembly Beta-tubulin Binding Regulation Of Synapse Organization Regulation Of Neuronal Synaptic Plasticity Protein Destabilization Amyloid-beta Complex Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Terminal Button Organization Regulation Of Amine Transport Positive Regulation Of Protein Localization To Cell Periphery Adult Locomotory Behavior Regulation Of Inflammatory Response Response To Interleukin-1 Negative Regulation Of Transport Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Protein Tetramerization Vesicle-mediated Transport In Synapse Acetylcholine Receptor Activator Activity Modulation Of Chemical Synaptic Transmission
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