DEFB118 and GUCA1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEFB118	GUCA1A
Description		defensin beta 118	guanylate cyclase activator 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Cell Projection Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment
	Molecular Function	Lipopolysaccharide Binding Protein Binding Membrane Destabilizing Activity	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity Metal Ion Binding
	Biological Process	Defense Response Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Spermatogenesis Killing Of Cells Of Another Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion
Pathways		Beta defensins Defensins	Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Myristic acid
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Prudent dietary pattern ( 28644415) TPE interval (resting) ( 32386560)	Femur bone mineral density x serum urate levels interaction ( 34046847) Spatial processing ( 31596458)
Interacting Genes		1 interacting genes: GUCA1A	10 interacting genes: AGR2 BCKDK C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B
Entrez ID		117285	2978
HPRD ID		09629	02648
Ensembl ID		ENSG00000131068	ENSG00000048545
Uniprot IDs		A0A384MTK2 Q96PH6	P43080
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Guanylate Cyclase Activity Guanylate Cyclase Regulator Activity Positive Regulation Of CGMP-mediated Signaling Calcium Sensitive Guanylate Cyclase Activator Activity Cone Photoreceptor Outer Segment Regulation Of CGMP-mediated Signaling Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity Photoreceptor Disc Membrane Phototransduction Photoreceptor Inner Segment Detection Of Light Stimulus Photoreceptor Outer Segment Cellular Response To Calcium Ion Regulation Of Purine Nucleotide Metabolic Process Detection Of Abiotic Stimulus Response To Calcium Ion Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Metal Ion Visual Perception Sensory Perception Of Light Stimulus Detection Of Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Small Molecule Metabolic Process Response To Metal Ion Response To Light Stimulus
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