UCN3 and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 11416224)
40

Data Source:
HPRD (two hybrid, in vitro)

		UCN3	CRHR2
Description		urocortin 3	corticotropin releasing hormone receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Varicosity Axon Terminus	Plasma Membrane Membrane Dendrite Axon Terminus
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Corticotropin-releasing Hormone Receptor Binding Corticotropin-releasing Hormone Receptor 2 Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Digestion Response To Glucose Hormone-mediated Signaling Pathway Cellular Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Immobilization Stress Response To Starvation Positive Regulation Of Membrane Potential Response To Corticosterone Cellular Response To Hypoxia	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Class B/2 (Secretin family receptors)	G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Intelligence ( 22449649)	Type 2 diabetes ( 24509480 30297969)
Interacting Genes		3 interacting genes: CRHR1 CRHR2 IL10RB	8 interacting genes: APP CRH GCC1 GPR35 MALL UCN UCN2 UCN3
Entrez ID		114131	1395
HPRD ID		12066	03614
Ensembl ID		ENSG00000178473	ENSG00000106113
Uniprot IDs		Q969E3	A0A090N7T4 Q13324
PDB IDs		2RMH 3N93	3N93 3N95 3N96 6PB1 7TRY 7TS0
Enriched GO Terms of Interacting Partners?		Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Cellular Response To Corticotropin-releasing Hormone Stimulus G Protein-coupled Peptide Receptor Activity Cellular Response To Peptide Hormone Stimulus Corticotropin-releasing Hormone Binding Hormone-mediated Signaling Pathway Corticotropin Secretion Interleukin-10 Receptor Activity Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Interleukin-28 Receptor Complex General Adaptation Syndrome, Behavioral Process Response To Peptide Hormone Regulation Of Corticosterone Secretion Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Parturition Behavioral Response To Ethanol Cell Surface Receptor Signaling Pathway Type III Interferon-mediated Signaling Pathway Interleukin-10-mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Respiration Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity Response To Hormone Adrenal Gland Development Negative Regulation Of Transporter Activity G Protein-coupled Receptor Signaling Pathway Exploration Behavior Negative Regulation Of Calcium Ion Transmembrane Transport Peptide Hormone Binding Fear Response Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Regulation Of Signaling Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Cellular Respiration Negative Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Axon Terminus Coreceptor Activity Peptide Hormone Secretion Negative Regulation Of Cation Transmembrane Transport Multicellular Organismal Response To Stress	Corticotropin-releasing Hormone Receptor 2 Binding Varicosity Positive Regulation Of CAMP/PKA Signal Transduction Hormone Activity Corticotropin-releasing Hormone Receptor Binding Regulation Of CAMP/PKA Signal Transduction Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Calcium Ion Transport Positive Regulation Of Corticotropin Secretion G Protein-coupled Receptor Binding Positive Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Positive Regulation Of Fear Response Associative Learning G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Response To Corticosterone Response To Glucocorticoid Response To Pain Perikaryon Hormone-mediated Signaling Pathway Positive Regulation Of Hormone Secretion Response To Auditory Stimulus Response To Corticosteroid Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Response To Immobilization Stress Positive Regulation Of Calcium Ion Import Positive Regulation Of Behavior Digestion Neuropeptide Hormone Activity Regulation Of Peptide Hormone Secretion Response To Steroid Hormone Response To Mineralocorticoid Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Calcium Ion Import Negative Regulation Of Blood Pressure Learning Or Memory Positive Regulation Of Secretion By Cell Regulation Of Transport Axon Terminus Cognition Positive Regulation Of Establishment Of Protein Localization
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