SYNPO and G3BP1

		SYNPO	G3BP1
Description		synaptopodin	G3BP stress granule assembly factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Postsynaptic Density Actin Cytoskeleton Z Disc Cell Projection Dendritic Spine Perikaryon Organelle Synapse Anchoring Junction Spine Apparatus Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon
	Molecular Function	Actin Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity DNA/RNA Helicase Activity Ribosomal Small Subunit Binding Molecular Condensate Scaffold Activity
	Biological Process	Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Spine Apparatus Assembly	Immune System Process Ras Protein Signal Transduction Positive Regulation Of Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401)	Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: CDC5L G3BP1 MAGI1 NCK1 NCK2 NDST1 NONO NUFIP2 SGF29 YWHAG YWHAZ	27 interacting genes: APP CEBPA CSK DNAH1 DTX1 EPHA8 FBXO25 GABARAP GABARAPL1 HAND1 HMGXB3 IL7R LCK LGALS8 LINC01554 OGT PIN1 PPIA RASA1 SPOP SYNPO TRIM21 TRIM25 UBAP2L USP10 USP13 USP2
Entrez ID		11346	10146
HPRD ID		12179	06569
Ensembl ID		ENSG00000171992	ENSG00000145907
Uniprot IDs		Q8N3V7	Q13283 Q5U0Q1 Q6ZP53
PDB IDs			3Q90 4FCJ 4FCM 4IIA 5FW5 6TA7 7S17 7SUO 7XHF 7XHG 8TH1 8TH5 8TH6 8TH7 8V1L
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Protein Sequestering Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Domain Specific Binding Response To Stress Positive Regulation Of Translation In Response To Stress Receptor Tyrosine Kinase Binding Signal Complex Assembly Cellular Response To Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation Positive Regulation Of Cell-cell Adhesion Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Intracellular Signal Transduction Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Signal Transduction Positive Regulation Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling RNA Binding Signaling Receptor Complex Adaptor Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Intrinsic Apoptotic Signaling Pathway Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Positive Regulation Of Response To Endoplasmic Reticulum Stress Lamellipodium Organization Response To Endoplasmic Reticulum Stress Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Molecular Condensate Scaffold Activity Cellular Response To Glucose Starvation Negative Regulation Of Response To Endoplasmic Reticulum Stress Ephrin Receptor Signaling Pathway Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Protein Modification Process Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Autophagy Protein Peptidyl-prolyl Isomerization Regulation Of Signal Transduction Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cytoplasm Stress Granule Assembly Regulation Of Proteolysis Positive Regulation Of Cell Activation Post-translational Protein Modification Cellular Developmental Process Protein Metabolic Process Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Activation Regulation Of Cell Communication Regulation Of Signaling T Cell Costimulation Heparan Sulfate Binding Organelle Assembly Protein Monoubiquitination Mitophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Stress Granule Assembly Mononuclear Cell Differentiation Cysteine-type Endopeptidase Activity Hemopoiesis Macromolecule Metabolic Process Response To Cytokine Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Response To Peptide Neuron Remodeling Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Intracellular Signal Transduction Regulation Of Protein Stability Leukocyte Differentiation Regulation Of Proteasomal Protein Catabolic Process Autophagosome Positive Regulation Of Protein Catabolic Process Regulation Of Leukocyte Cell-cell Adhesion Protein Ubiquitination Suppression Of Viral Release By Host GABA Receptor Binding Regulation Of T Cell Activation Regulation Of Protein Metabolic Process
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