G3BP1

Description		G3BP stress granule assembly factor 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity DNA/RNA Helicase Activity Ribosomal Small Subunit Binding Molecular Condensate Scaffold Activity
	Biological Process	Immune System Process Ras Protein Signal Transduction Positive Regulation Of Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)
Novel Interacting Genes		27 novel interacting genes: APP CEBPA CSK DNAH1 DTX1 EPHA8 FBXO25 GABARAP GABARAPL1 HAND1 HMGXB3 IL7R LCK LGALS8 LINC01554 OGT PIN1 PPIA RASA1 SPOP SYNPO TRIM21 TRIM25 UBAP2L USP10 USP13 USP2
Interacting Genes		27 interacting genes: APP CEBPA CSK DNAH1 DTX1 EPHA8 FBXO25 GABARAP GABARAPL1 HAND1 HMGXB3 IL7R LCK LGALS8 LINC01554 OGT PIN1 PPIA RASA1 SPOP SYNPO TRIM21 TRIM25 UBAP2L USP10 USP13 USP2
Entrez ID		10146
HPRD ID		06569
Ensembl ID		ENSG00000145907
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5 6TA7 7S17 7SUO 7XHF 7XHG 8TH1 8TH5 8TH6 8TH7 8V1L
Enriched GO Terms of Interacting Partners?		Protein Modification Process Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Autophagy Protein Peptidyl-prolyl Isomerization Regulation Of Signal Transduction Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cytoplasm Stress Granule Assembly Regulation Of Proteolysis Positive Regulation Of Cell Activation Post-translational Protein Modification Cellular Developmental Process Protein Metabolic Process Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Activation Regulation Of Cell Communication Regulation Of Signaling T Cell Costimulation Heparan Sulfate Binding Organelle Assembly Protein Monoubiquitination Mitophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Stress Granule Assembly Mononuclear Cell Differentiation Cysteine-type Endopeptidase Activity Hemopoiesis Macromolecule Metabolic Process Response To Cytokine Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Response To Peptide Neuron Remodeling Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Intracellular Signal Transduction Regulation Of Protein Stability Leukocyte Differentiation Regulation Of Proteasomal Protein Catabolic Process Autophagosome Positive Regulation Of Protein Catabolic Process Regulation Of Leukocyte Cell-cell Adhesion Protein Ubiquitination Suppression Of Viral Release By Host GABA Receptor Binding Regulation Of T Cell Activation Regulation Of Protein Metabolic Process
Tagcloud ?