G3BP1 and USP13

Number of citations of the paper that reports this interaction (PubMedID 36183834)
84

Data Source:
BioGRID (imaging technique, unspecified method)

		G3BP1	USP13
Description		G3BP stress granule assembly factor 1	ubiquitin specific peptidase 13
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity DNA/RNA Helicase Activity Ribosomal Small Subunit Binding Molecular Condensate Scaffold Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Protein-folding Chaperone Binding Proteasome Binding BAT3 Complex Binding K48-linked Deubiquitinase Activity
	Biological Process	Immune System Process Ras Protein Signal Transduction Positive Regulation Of Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of DNA-templated Transcription Proteolysis Autophagy Cell Population Proliferation Regulation Of Autophagy Protein Deubiquitination Melanocyte Differentiation Regulation Of Protein Stability Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses	Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		27 interacting genes: APP CEBPA CSK DNAH1 DTX1 EPHA8 FBXO25 GABARAP GABARAPL1 HAND1 HMGXB3 IL7R LCK LGALS8 LINC01554 OGT PIN1 PPIA RASA1 SPOP SYNPO TRIM21 TRIM25 UBAP2L USP10 USP13 USP2	30 interacting genes: AMFR ATG5 CCND1 CLK3 CSNK2A1 CTNNB1 DAZAP2 DVL1 DYRK1A FNBP1L FUNDC2 G3BP1 GPR160 HSP90AA1 LAPTM5 MDC1 MRPL20 MYO15A S100A9 SIAH2 SPRR2C SYCP2 TOPBP1 TRA2B TRIM55 TRIM63 TWIST1 UBC UBL4A UIMC1
Entrez ID		10146	8975
HPRD ID		06569	04666
Ensembl ID		ENSG00000145907	ENSG00000058056
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	A0A0A6YZ17 Q92995
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5 6TA7 7S17 7SUO 7XHF 7XHG 8TH1 8TH5 8TH6 8TH7 8V1L	2L80 2LBC
Enriched GO Terms of Interacting Partners?		Protein Modification Process Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Autophagy Protein Peptidyl-prolyl Isomerization Regulation Of Signal Transduction Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cytoplasm Stress Granule Assembly Regulation Of Proteolysis Positive Regulation Of Cell Activation Post-translational Protein Modification Cellular Developmental Process Protein Metabolic Process Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Activation Regulation Of Cell Communication Regulation Of Signaling T Cell Costimulation Heparan Sulfate Binding Organelle Assembly Protein Monoubiquitination Mitophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Stress Granule Assembly Mononuclear Cell Differentiation Cysteine-type Endopeptidase Activity Hemopoiesis Macromolecule Metabolic Process Response To Cytokine Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Response To Peptide Neuron Remodeling Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Intracellular Signal Transduction Regulation Of Protein Stability Leukocyte Differentiation Regulation Of Proteasomal Protein Catabolic Process Autophagosome Positive Regulation Of Protein Catabolic Process Regulation Of Leukocyte Cell-cell Adhesion Protein Ubiquitination Suppression Of Viral Release By Host GABA Receptor Binding Regulation Of T Cell Activation Regulation Of Protein Metabolic Process	DNA Damage Checkpoint Signaling Protein Modification Process Wnt Signaling Pathway Protein Ubiquitination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Autophagic Cell Death Autophagy Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Intracellular Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Protein Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Negative Regulation Of Signal Transduction By P53 Class Mediator Post-translational Protein Modification Response To Stress Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Cycle Process Identical Protein Binding Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Stress Granule Assembly Ubiquitin Protein Ligase Binding Regulation Of DNA Metabolic Process Genitalia Morphogenesis Regulation Of Wnt Signaling Pathway Cellular Response To Stress Negative Regulation Of Wnt Signaling Pathway Wnt Signalosome Cardiac Muscle Cell Apoptotic Process Catabolic Process Protein Serine/threonine Kinase Activator Activity Nucleus Aggrephagy Striated Muscle Cell Apoptotic Process Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Protein-containing Complex Macromolecule Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catabolic Process
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