C12orf57 and INSL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C12orf57	INSL3
Description		chromosome 12 open reading frame 57	insulin like 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Nuclear Speck	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding	Protease Binding Signaling Receptor Binding Insulin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Post-embryonic Development Regulation Of Skeletal Muscle Contraction Corpus Callosum Morphogenesis Third Ventricle Development Psychomotor Behavior Camera-type Eye Morphogenesis Cognition	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Wound Healing
Pathways			G alpha (s) signalling events Relaxin receptors
Drugs
Diseases			46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS		Refractive error ( 32231278)
Interacting Genes		2 interacting genes: ANKK1 INSL3	3 interacting genes: C12orf57 RBPJ RXFP2
Entrez ID		113246	3640
HPRD ID		13609	08854
Ensembl ID		ENSG00000111678	ENSG00000248099
Uniprot IDs		F5GXW5 Q99622 U3KQ85	P51460
PDB IDs			2H8B 2K6T 2K6U
Enriched GO Terms of Interacting Partners?			MAML1-RBP-Jkappa- ICN1 Complex Developmental Maturation Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Ephrin Receptor Signaling Pathway Club Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Blood Vessel Endothelial Cell Fate Specification Hair Follicle Maturation Blood Vessel Lumenization Endocardium Development Arterial Endothelial Cell Fate Commitment Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Semi-lunar Valve Development Regulation Of Cell Adhesion Involved In Heart Morphogenesis Corpus Callosum Morphogenesis Psychomotor Behavior Third Ventricle Development Positive Regulation Of Transcription Of Notch Receptor Target Sebaceous Gland Development Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Endothelial Tube Morphogenesis Heart Field Specification Atrioventricular Canal Development Epithelial Cell Fate Commitment Secondary Heart Field Specification Cardiac Left Ventricle Morphogenesis Protein-hormone Receptor Activity Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Ventricular Trabecula Myocardium Morphogenesis Regulation Of Development, Heterochronic Specification Of Animal Organ Identity Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Skeletal Muscle Contraction Labyrinthine Layer Blood Vessel Development Heart Trabecula Morphogenesis Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation Lung Epithelial Cell Differentiation Heart Valve Development Aorta Morphogenesis Negative Regulation Of Stem Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Muscle Cell Proliferation
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