INSL3 and RXFP2

Number of citations of the paper that reports this interaction (PubMedID 12114498)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		INSL3	RXFP2
Description		insulin like 3	relaxin family peptide receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane
	Molecular Function	Protease Binding Signaling Receptor Binding Insulin Receptor Binding Hormone Activity Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Wound Healing	Oocyte Maturation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways		G alpha (s) signalling events Relaxin receptors	G alpha (s) signalling events Relaxin receptors
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism	46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS			Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		3 interacting genes: C12orf57 RBPJ RXFP2	2 interacting genes: INSL3 RLN2
Entrez ID		3640	122042
HPRD ID		08854	05976
Ensembl ID		ENSG00000248099	ENSG00000133105
Uniprot IDs		P51460	Q8WXD0
PDB IDs		2H8B 2K6T 2K6U	2M96
Enriched GO Terms of Interacting Partners?		MAML1-RBP-Jkappa- ICN1 Complex Developmental Maturation Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Ephrin Receptor Signaling Pathway Club Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Blood Vessel Endothelial Cell Fate Specification Hair Follicle Maturation Blood Vessel Lumenization Endocardium Development Arterial Endothelial Cell Fate Commitment Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Semi-lunar Valve Development Regulation Of Cell Adhesion Involved In Heart Morphogenesis Corpus Callosum Morphogenesis Psychomotor Behavior Third Ventricle Development Positive Regulation Of Transcription Of Notch Receptor Target Sebaceous Gland Development Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Endothelial Tube Morphogenesis Heart Field Specification Atrioventricular Canal Development Epithelial Cell Fate Commitment Secondary Heart Field Specification Cardiac Left Ventricle Morphogenesis Protein-hormone Receptor Activity Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Ventricular Trabecula Myocardium Morphogenesis Regulation Of Development, Heterochronic Specification Of Animal Organ Identity Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Skeletal Muscle Contraction Labyrinthine Layer Blood Vessel Development Heart Trabecula Morphogenesis Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation Lung Epithelial Cell Differentiation Heart Valve Development Aorta Morphogenesis Negative Regulation Of Stem Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Muscle Cell Proliferation	Hormone Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?