MGAT4A and RRM2

		MGAT4A	RRM2
Description		alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A	ribonucleotide reductase regulatory subunit M2
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Stack Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Acetylglucosaminyltransferase Activity Alanine-glyoxylate Transaminase Activity Alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Protein Homodimerization Activity Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation N-glycan Processing Viral Protein Processing Glyoxylate Metabolic Process	Blastocyst Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Maturation of spike protein N-Glycan antennae elongation	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs			Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Bipolar disorder ( 21738484 21926972 31043756) Idiopathic inflammatory myopathy ( 26362759) Left ventricular obstructive tract defect (inherited effect) ( 28468790)	Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)
Interacting Genes		1 interacting genes: RRM2	20 interacting genes: ASAP2 BARX1 CDH1 CDK1 DNM1L GCG ITSN2 KAT5 LAPTM4A LPIN1 MGAT4A NPBWR2 PLK3 RRM1 RRM2B SDCBP ST3GAL3 TAF1B TP53 USP12
Entrez ID		11320	6241
HPRD ID		06860	01587
Ensembl ID		ENSG00000071073	ENSG00000171848
Uniprot IDs		Q9UM21	P31350
PDB IDs		7XTL	2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?		Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization 2'-deoxyribonucleotide Biosynthetic Process Ferric Iron Binding Blastocyst Development Protein Heterooligomerization Deoxyribonucleotide Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Nucleoside Diphosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Tetramerization Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Nucleotide Biosynthetic Process Protein Complex Oligomerization Positive Regulation Of Cell Cycle Process Nucleoside Phosphate Biosynthetic Process	Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Mitochondrial DNA Metabolic Process Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G0 To G1 Transition Golgi Disassembly Regulation Of Mitotic Cell Cycle Positive Regulation Of Establishment Of Protein Localization Signal Transduction In Response To DNA Damage DNA-templated DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Nuclear Membrane Disassembly Mitochondrial DNA Replication Organelle Disassembly Regulation Of Metaphase Plate Congression Regulation Of Cell Cycle Phase Transition Nuclear Membrane Disassembly Regulation Of Protein Transport Regulation Of Cell Cycle Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Membrane Disassembly Positive Regulation Of Intracellular Protein Transport DNA Biosynthetic Process Carbohydrate Derivative Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Triglyceride Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process DNA Damage Response Signal Transduction By P53 Class Mediator DNA Repair Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization Positive Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Cell Cycle Phase Transition Regulation Of Attachment Of Spindle Microtubules To Kinetochore RRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator
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