STRAP and NEIL3

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		STRAP	NEIL3
Description		serine/threonine kinase receptor associated protein	nei like DNA glycosylase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex	Nucleus Nucleoplasm Chromosome
	Molecular Function	RNA Binding MRNA Binding Signaling Receptor Binding Protein Binding U2 SnRNP Binding	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein-RNA Complex Assembly Neuron Differentiation Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Positive Regulation of CDH1 Gene Transcription	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
Drugs
Diseases
GWAS			Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)
Interacting Genes		31 interacting genes: ANXA1 CEBPA CHEK2 FOXP1 GEMIN6 GEMIN7 MAP1B MTRES1 NEIL3 NXF1 PBLD PDPK1 PTEN RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO2 SUMO4 SZRD1 TGFBR1 TGFBR2	54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B
Entrez ID		11171	55247
HPRD ID		05816	16407
Ensembl ID		ENSG00000023734	ENSG00000109674
Uniprot IDs		Q9Y3F4	Q8TAT5
PDB IDs			7JL5 7TMY
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex I-SMAD Binding Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly Heteromeric SMAD Protein Complex 7-methylguanosine Cap Hypermethylation SMAD Protein Signal Transduction U2 SnRNP Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein-RNA Complex Assembly Type I Transforming Growth Factor Beta Receptor Binding U4 SnRNP Response To Growth Factor Methylosome Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Small Nuclear Ribonucleoprotein Complex Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway U1 SnRNP Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway U5 SnRNP Regulation Of Epithelial To Mesenchymal Transition RNA Splicing, Via Transesterification Reactions Activin Receptor Binding U2-type Prespliceosome Assembly U12-type Spliceosomal Complex PICln-Sm Protein Complex Nucleoplasm R-SMAD Binding Regulation Of SMAD Protein Signal Transduction Trophoblast Cell Migration U7 SnRNP U2-type Spliceosomal Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Ureteric Bud Development SMN Complex Ubiquitin Protein Ligase Binding Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Ossification Co-SMAD Binding Gemini Of Cajal Bodies Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA Splicing, Via Spliceosome Mesonephric Tubule Development Mesonephric Epithelium Development SMAD Binding	RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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