STRAP and GEMIN6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		STRAP	GEMIN6
Description		serine/threonine kinase receptor associated protein	gem nuclear organelle associated protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies
	Molecular Function	RNA Binding MRNA Binding Signaling Receptor Binding Protein Binding U2 SnRNP Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein-RNA Complex Assembly Neuron Differentiation Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Positive Regulation of CDH1 Gene Transcription	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS
Interacting Genes		31 interacting genes: ANXA1 CEBPA CHEK2 FOXP1 GEMIN6 GEMIN7 MAP1B MTRES1 NEIL3 NXF1 PBLD PDPK1 PTEN RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO2 SUMO4 SZRD1 TGFBR1 TGFBR2	16 interacting genes: ACOT11 DDIT4L GEMIN7 NUFIP1 RASL11B RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD2 SNRPD3 SNRPE SNRPF SNRPG STRAP TOX4
Entrez ID		11171	79833
HPRD ID		05816	06110
Ensembl ID		ENSG00000023734	ENSG00000152147
Uniprot IDs		Q9Y3F4	Q8WXD5
PDB IDs			1Y96 7BBL
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex I-SMAD Binding Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly Heteromeric SMAD Protein Complex 7-methylguanosine Cap Hypermethylation SMAD Protein Signal Transduction U2 SnRNP Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein-RNA Complex Assembly Type I Transforming Growth Factor Beta Receptor Binding U4 SnRNP Response To Growth Factor Methylosome Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Small Nuclear Ribonucleoprotein Complex Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway U1 SnRNP Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway U5 SnRNP Regulation Of Epithelial To Mesenchymal Transition RNA Splicing, Via Transesterification Reactions Activin Receptor Binding U2-type Prespliceosome Assembly U12-type Spliceosomal Complex PICln-Sm Protein Complex Nucleoplasm R-SMAD Binding Regulation Of SMAD Protein Signal Transduction Trophoblast Cell Migration U7 SnRNP U2-type Spliceosomal Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Ureteric Bud Development SMN Complex Ubiquitin Protein Ligase Binding Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Ossification Co-SMAD Binding Gemini Of Cajal Bodies Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA Splicing, Via Spliceosome Mesonephric Tubule Development Mesonephric Epithelium Development SMAD Binding	SMN-Sm Protein Complex 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly U2 SnRNP U4 SnRNP Methylosome Protein-RNA Complex Assembly Small Nuclear Ribonucleoprotein Complex U1 SnRNP U7 SnRNP U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex RNA Methylation Catalytic Step 2 Spliceosome RNA Splicing Macromolecule Methylation Protein-containing Complex Assembly MRNA Processing Precatalytic Spliceosome Protein-containing Complex Organization RNA Modification Spliceosomal Complex RNA Processing Methylation MRNA Metabolic Process Ribonucleoprotein Complex U2 SnRNP Binding Cellular Component Assembly Telomerase Holoenzyme Complex RNA Metabolic Process RNA Binding Histone Pre-mRNA DCP Binding Spliceosomal Tri-snRNP Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process SMN Complex U2-type Prespliceosome Telomerase RNA Binding Protein Methylation Pre-mRNA Branch Point Binding MRNA Branch Site Recognition
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