NEIL3 and HDLBP

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		NEIL3	HDLBP
Description		nei like DNA glycosylase 3	high density lipoprotein binding protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Nucleus Cytoplasm Plasma Membrane High-density Lipoprotein Particle
	Molecular Function	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Lipid Binding Cadherin Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs	HDL clearance
Drugs
Diseases
GWAS		Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Fibrinogen levels ( 26561523 28107422) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29617998) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B	18 interacting genes: ADAR CDC42 CEBPA DHX9 ERBB2 ESR1 FILNC1 HMGB1 HMGB2 HSPB1 NEIL3 PLXNB2 RNF10 SMAD4 SOS1 SUMO2 TENT5A XPOT
Entrez ID		55247	3069
HPRD ID		16407	00813
Ensembl ID		ENSG00000109674	ENSG00000115677
Uniprot IDs		Q8TAT5	A0A024R4E5 B2R5V9 Q00341
PDB IDs		7JL5 7TMY	1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Single-stranded DNA Binding Regulation Of Developmental Process Transcription Cis-regulatory Region Binding Regulation Of Cell Differentiation Double-stranded DNA Binding Positive Regulation Of Interferon-beta Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Supercoiled DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Metabolic Process DNA Geometric Change Bubble DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Interferon-beta Production Positive Regulation Of Viral Process Negative Regulation Of RNA Metabolic Process Damaged DNA Binding RISC Complex Assembly DNA Topological Change Positive Regulation Of Epithelial Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Double-stranded RNA Binding Response To Stress RNA Binding Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis Cell Population Proliferation RAGE Receptor Binding Regulation Of Innate Immune Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization Protein-containing Complex
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