FICD and ADK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FICD	ADK
Description		FIC domain protein adenylyltransferase	adenosine kinase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Adenylylhydrolase Activity Protein-folding Chaperone Binding AMPylase Activity	Nucleotide Binding RNA Binding Adenosine Kinase Activity Deoxyadenosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Response To Unfolded Protein Protein Adenylylation Negative Regulation Of GTPase Activity Response To Endoplasmic Reticulum Stress Protein Deadenylylation Regulation Of IRE1-mediated Unfolded Protein Response	Purine Nucleobase Metabolic Process Purine Ribonucleoside Salvage DATP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process GMP Salvage AMP Salvage DAMP Salvage
Pathways			Purine salvage Ribavirin ADME
Drugs			Adenosine phosphate 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE
Diseases
GWAS		Acne (severe) ( 24927181) Obesity-related traits ( 23251661) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Adult body size ( 32376654) Cardiac troponin-I levels ( 31014085) Diverticular disease ( 30177863) Drug experimentation measurement ( 30718321) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypospadias ( 25108383) Lymphocyte count ( 32888494) Permanent tooth development ( 21931568) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 30578418)
Interacting Genes		2 interacting genes: ADK HTT	3 interacting genes: FICD PLEKHA5 SRD5A3
Entrez ID		11153	132
HPRD ID		13723	00039
Ensembl ID		ENSG00000198855	ENSG00000156110
Uniprot IDs		Q9BVA6	A0A140VJE0 A0A5F9ZH31 A0A5F9ZH72 A0A5F9ZHJ1 P55263
PDB IDs		4U04 4U07 4U0S 4U0U 4U0Z 6I7G 6I7H 6I7I 6I7J 6I7K 6I7L 6ZMD 7B7Z 7B80	1BX4 2I6A 2I6B 4O1L
Enriched GO Terms of Interacting Partners?		DATP Biosynthetic Process Adenosine Kinase Activity Deoxyadenosine Kinase Activity DAMP Salvage Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of CAMKK-AMPK Signaling Cascade GMP Salvage DATP Metabolic Process Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Positive Regulation Of Lipophagy Purine Ribonucleoside Salvage AMP Salvage Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Vocal Learning Profilin Binding Observational Learning Nucleoside Salvage 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process GMP Biosynthetic Process AMP Biosynthetic Process Auditory Behavior Dynactin Binding Mechanosensory Behavior Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Inclusion Body AMP Metabolic Process Positive Regulation Of Mitophagy Positive Regulation Of Cation Channel Activity Purine Nucleoside Metabolic Process Purine Nucleotide Salvage Positive Regulation Of Autophagy Of Mitochondrion GMP Metabolic Process Presynaptic Cytosol Postsynaptic Cytosol Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Ion Transmembrane Transporter Activity Dynein Intermediate Chain Binding Positive Regulation Of Cilium Assembly Synaptic Vesicle Transport Establishment Of Mitotic Spindle Orientation Nucleoside Monophosphate Biosynthetic Process Deoxyribonucleotide Metabolic Process Establishment Of Mitotic Spindle Localization	Protein Adenylylhydrolase Activity AMPylase Activity Protein Adenylylation Protein Deadenylylation Polyprenol Reductase Activity Polyprenal Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process Negative Regulation Of GTPase Activity Regulation Of IRE1-mediated Unfolded Protein Response Dolichol-linked Oligosaccharide Biosynthetic Process Phosphatidylinositol-5-phosphate Binding Reproductive System Development Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Androgen Metabolic Process Steroid Hormone Biosynthetic Process Alcohol Catabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Hormone Biosynthetic Process Phosphatidylinositol-3-phosphate Binding Hsp70 Protein Binding Endoplasmic Reticulum Membrane Response To Unfolded Protein Steroid Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Protein-folding Chaperone Binding Nucleotidyltransferase Activity Isoprenoid Metabolic Process
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