PRDM4 and DAO

		PRDM4	DAO
Description		PR/SET domain 4	D-amino acid oxidase
Image
GO Annotations	Cellular Component	Nucleus Histone Methyltransferase Complex	Extracellular Region Extracellular Space Cytoplasm Mitochondrial Outer Membrane Peroxisome Peroxisomal Matrix Cytosol Cell Projection Synapse Presynaptic Active Zone
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding	D-amino-acid Oxidase Activity Protein Binding D-amino-acid Dehydrogenase Activity Oxidoreductase Activity Identical Protein Binding Glycine Oxidase Activity FAD Binding
	Biological Process	Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Positive Regulation Of Transcription By RNA Polymerase II	L-leucine Metabolic Process L-proline Catabolic Process Digestion D-amino Acid Catabolic Process D-serine Catabolic Process Dopamine Biosynthetic Process D-amino Acid Metabolic Process Killing By Host Of Symbiont Cells D-alanine Catabolic Process D-serine Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process
Pathways		p75NTR negatively regulates cell cycle via SC1	Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs			3,4-Dihydro-2h-Pyrrolium-5-Carboxylate Imino-Tryptophan Flavin adenine dinucleotide D-Tryptophan Flavin-adenine dinucleotide-N5-isobutyl ketone Benzoic acid Anthranilic acid (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
Diseases
GWAS		Acne (severe) ( 24927181) Daytime nap ( 33568662) Sleep duration ( 30846698)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Nicotine dependence and major depression (severity of comorbidity) ( 30287806)
Interacting Genes		13 interacting genes: CFTR CTNNBL1 DAO DYRK1A EIF4E EMX1 MSRB3 NCS1 RCAN1 RUNX1 SERTAD1 SMAD3 UNG	10 interacting genes: AOC1 ATP2B1 CCAR1 DAOA EP300 FBXO21 PEX5 PRDM4 PRKAB2 UNG
Entrez ID		11108	1610
HPRD ID		10425	15917
Ensembl ID		ENSG00000110851	ENSG00000110887
Uniprot IDs		B3KPI0 Q9UKN5	A0A024RBI1 A0A0S2Z3J4 P14920
PDB IDs		2L9Z 3DB5	2DU8 2E48 2E49 2E4A 2E82 3CUK 3G3E 3W4I 3W4J 3W4K 3ZNN 3ZNO 3ZNP 3ZNQ 4QFC 4QFD 5ZJ9 5ZJA 6KBP 7U9S 7U9U 8HY5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extracellular Matrix Organization Transcription Coactivator Binding DNA-binding Transcription Factor Binding Transcription Corepressor Binding Enzyme Binding Response To Stress Positive Regulation Of Biomineral Tissue Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Histone H3T45 Kinase Activity Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Somatic Diversification Of Immunoglobulins	Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Peptidyl-lysine Propionylation Carboxylic Acid Metabolic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Organic Acid Metabolic Process Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Damaged DNA Binding Small Molecule Metabolic Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Nucleotide Catabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Peroxisome Targeting Sequence Binding Peroxisome Monocarboxylic Acid Metabolic Process Negative Regulation Of Protein Oligomerization Nucleoside Phosphate Catabolic Process Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Uracil DNA N-glycosylase Activity D-amino Acid Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?