DAO and CCAR1

		DAO	CCAR1
Description		D-amino acid oxidase	cell division cycle and apoptosis regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Mitochondrial Outer Membrane Peroxisome Peroxisomal Matrix Cytosol Cell Projection Synapse Presynaptic Active Zone	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	D-amino-acid Oxidase Activity Protein Binding D-amino-acid Dehydrogenase Activity Oxidoreductase Activity Identical Protein Binding Glycine Oxidase Activity FAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	L-leucine Metabolic Process L-proline Catabolic Process Digestion D-amino Acid Catabolic Process D-serine Catabolic Process Dopamine Biosynthetic Process D-amino Acid Metabolic Process Killing By Host Of Symbiont Cells D-alanine Catabolic Process D-serine Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process	Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import	mRNA Splicing - Major Pathway
Drugs		3,4-Dihydro-2h-Pyrrolium-5-Carboxylate Imino-Tryptophan Flavin adenine dinucleotide D-Tryptophan Flavin-adenine dinucleotide-N5-isobutyl ketone Benzoic acid Anthranilic acid (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Nicotine dependence and major depression (severity of comorbidity) ( 30287806)	Cannabis dependence symptom count ( 27028160)
Interacting Genes		10 interacting genes: AOC1 ATP2B1 CCAR1 DAOA EP300 FBXO21 PEX5 PRDM4 PRKAB2 UNG	19 interacting genes: CASP10 CHERP CTNNB1 DAO DNAAF6 GOLGA2 HMGB1 HNRNPK HUNK MDM2 MIR106B MIRLET7G MTUS2 RBM10 RNF10 RNF113A SFN U2AF2 USP7
Entrez ID		1610	55749
HPRD ID		15917	10811
Ensembl ID		ENSG00000110887	ENSG00000060339
Uniprot IDs		A0A024RBI1 A0A0S2Z3J4 P14920	Q8IX12
PDB IDs		2DU8 2E48 2E49 2E4A 2E82 3CUK 3G3E 3W4I 3W4J 3W4K 3ZNN 3ZNO 3ZNP 3ZNQ 4QFC 4QFD 5ZJ9 5ZJA 6KBP 7U9S 7U9U 8HY5
Enriched GO Terms of Interacting Partners?		Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Peptidyl-lysine Propionylation Carboxylic Acid Metabolic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Organic Acid Metabolic Process Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Damaged DNA Binding Small Molecule Metabolic Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Nucleotide Catabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Peroxisome Targeting Sequence Binding Peroxisome Monocarboxylic Acid Metabolic Process Negative Regulation Of Protein Oligomerization Nucleoside Phosphate Catabolic Process Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Uracil DNA N-glycosylase Activity D-amino Acid Metabolic Process	Negative Regulation Of Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Nucleocytoplasmic Transport Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Vasculature Development Disordered Domain Specific Binding Cadherin Binding Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Cell Population Proliferation Protein Modification By Small Protein Conjugation Epithelial Cell Proliferation Glial Cell Fate Determination Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gliogenesis Positive Regulation Of Angiogenesis Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Vasculature Development D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Regulation Of Protein Export From Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of Gene Expression, Epigenetic
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