DSTN and SSH1

Number of citations of the paper that reports this interaction (PubMedID 11832213)
0

Data Source:
BioGRID (enzymatic study)

		DSTN	SSH1
Description		destrin, actin depolymerizing factor	slingshot protein phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Cortical Actin Cytoskeleton Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Growth Cone Midbody Cell Leading Edge Cleavage Furrow Cell Projection Synapse
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Actin Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity
	Biological Process	Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Cell Motility Actin Filament Severing	Cell Morphogenesis Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Regulation Of Protein Metabolic Process Cellular Response To ATP Excitatory Chemical Synaptic Transmission Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Drugs		Dodecyldimethylamine N-oxide
Diseases
GWAS		Coronary artery disease ( 29212778) Presence of antiphospholipid antibodies ( 23509613)	Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252) Platelet count ( 32888494)
Interacting Genes		10 interacting genes: ACTB ACTG1 CFTR FNDC3B SHBG SMAD9 SSH1 TAX1BP1 TESK2 VHL	6 interacting genes: ACTB AKT1 CFL1 CFL2 CORO1B DSTN
Entrez ID		11034	54434
HPRD ID		16446	09486
Ensembl ID		ENSG00000125868	ENSG00000084112
Uniprot IDs		P60981 V9HWA6	Q8WYL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Postsynaptic Cytoskeleton Organization Actin Filament-based Process Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Actin Cytoskeleton Organization Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Platelet Aggregation Cell Junction Assembly Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Homotypic Cell-cell Adhesion Basal Body Patch Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Localization To Cell Junction Actin Filament Regulation Of Norepinephrine Uptake Positive Regulation Of Anion Channel Activity Protein Localization To Phagocytic Vesicle Positive Regulation Of AMPA Glutamate Receptor Clustering Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Cytoskeleton Organization Transporter Regulator Activity Positive Regulation Of Monoatomic Anion Transport Cell-cell Junction Assembly Cytoplasm Blood Microparticle Cell Junction Organization Multicellular Organismal-level Homeostasis Positive Regulation Of Enamel Mineralization Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Postsynaptic Membrane Organization Regulation Of Cellular Localization Protein Localization To Adherens Junction Transepithelial Water Transport Androgen Binding Response To Purine-containing Compound Regulation Of Vesicle-mediated Transport	Actin Filament Fragmentation Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Actin Filament Severing Positive Regulation Of Protein Depolymerization Actin Filament-based Process Regulation Of Organelle Organization Positive Regulation Of Protein-containing Complex Disassembly Protein Depolymerization Glutamatergic Synapse Lamellipodium Actin Filament Binding Regulation Of Actin Filament Depolymerization Actin Polymerization Or Depolymerization Actin Filament Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Regulation Of Actin Cytoskeleton Organization Nitric-oxide Synthase Regulator Activity Actin Cytoskeleton Organization Regulation Of Protein Depolymerization Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Cell Motility Cellular Response To Ether Positive Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Disassembly Nuclear Matrix Regulation Of Cellular Component Organization Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Protein-containing Complex Disassembly Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Vesicle Response To Ether Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Positive Regulation Of Lamellipodium Organization Regulation Of Cellular Component Size Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Response To Growth Factor Extracellular Exosome Regulation Of Lamellipodium Organization Response To Epidermal Growth Factor Cytoskeleton Organization
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