MAPRE2 and CLIP1

Number of citations of the paper that reports this interaction (PubMedID 16455083)
22

Data Source:
HPRD (in vitro)

		MAPRE2	CLIP1
Description		microtubule associated protein RP/EB family member 2	CAP-Gly domain containing linker protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Microtubule Plus-end Spindle Midzone	Kinetochore Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Microtubule Plus-end Cell Projection Macropinosome
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding	Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of ARF Protein Signal Transduction Protein Localization To Microtubule Spindle Assembly Cell Division Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Disassembly	Mitotic Cell Cycle Microtubule Bundle Formation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Signaling by LTK in cancer
Drugs
Diseases
GWAS		Brugada syndrome ( 35210625) Cerebrospinal fluid AB1-42 levels ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Metabolite levels ( 23823483)	A body shape index ( 34021172) Adiponectin levels ( 31178129) Body fat percentage and HDL-C (pairwise) ( 33619380) Body mass index ( 25673413 26961502) Body mass index and HDL-C (pairwise) ( 33619380) Chronotype ( 30696823) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		26 interacting genes: APC APP AURKA AURKB CASK CDK2 CDK4 CLASP2 CLIP1 DDIT4L FBXO7 GTSE1 KMT2E LMNA LMO2 LNX1 MAPRE3 NIF3L1 PAXIP1 RBM10 RBM6 SLAIN2 TRAF1 TRAIP TXN2 UBC	13 interacting genes: BIN1 CALM1 CLASP2 CLIP4 DCTN1 IQGAP1 MAPRE2 MTOR PAFAH1B1 REL TSC22D2 TUBA1A TUBB
Entrez ID		10982	6249
HPRD ID		16157	01568
Ensembl ID		ENSG00000166974	ENSG00000130779
Uniprot IDs		Q15555	B3KXA5 P30622
PDB IDs			2CP5 2CP6 2E3H 2E3I 2E4H 2HQH 2QK0 3E2U 3RDV 8WHH 8WHI
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Plus-end Binding Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Microtubule-based Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Supramolecular Fiber Organization Cytoplasmic Microtubule Regulation Of Microtubule Polymerization Centrosome Microtubule Cytoskeleton Organization Kinetochore Cell Cycle Phase Transition Microtubule Plus-end Spindle Midzone Regulation Of Cell Cycle Process Microtubule Spindle Assembly Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Depolymerization Positive Regulation Of Cellular Component Organization Cytoskeleton Chromosome Passenger Complex Spindle Microtubule Microtubule Binding Regulation Of Organelle Organization Positive Regulation Of Mitotic Cell Cycle Cell Division Membraneless Organelle Assembly Mitotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Binding Cell Cycle G2/M Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Identical Protein Binding Regulation Of Cell Cycle G1/S Phase Transition Protein Serine Kinase Activity Nuclear Lamina	Microtubule Microtubule Plus-end Binding Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Cytoplasmic Microtubule Cell Leading Edge Cell Cortex Cell Division Microtubule Plus-end Microtubule-based Process Regulation Of Cytoskeleton Organization Neuromuscular Process Cytoskeleton Establishment Of Mitotic Spindle Localization Protein-containing Complex Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Epithelial Cell Migration Organelle Assembly Cellular Component Assembly Establishment Of Spindle Localization Cytoskeleton-dependent Intracellular Transport Spindle Localization Organelle Organization Organelle Localization Regulation Of Epithelial Cell Migration Spindle Positive Regulation Of Keratinocyte Migration Microtubule Binding Microtubule Organizing Center Organization Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Establishment Of Organelle Localization Spindle Assembly Establishment Of Localization In Cell Regulation Of Microtubule Polymerization Or Depolymerization Nuclear Membrane Disassembly Regulation Of Synapse Organization Membrane Disassembly Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cellular Component Organization Regulation Of Organelle Organization Response To Calcium Ion Mitotic Spindle Microtubule Anchoring Mitotic Cell Cycle Regulation Of Supramolecular Fiber Organization
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