CLIP1 and IQGAP1

Number of citations of the paper that reports this interaction (PubMedID 12110184)
0

Data Source:
HPRD (in vitro, in vivo)

		CLIP1	IQGAP1
Description		CAP-Gly domain containing linker protein 1	IQ motif containing GTPase activating protein 1
Image
GO Annotations	Cellular Component	Kinetochore Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Microtubule Plus-end Cell Projection Macropinosome	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Cortical Actin Cytoskeleton Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Exosome Plasma Membrane Bounded Cell Projection Ribonucleoprotein Complex
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Molecular Adaptor Activity
	Biological Process	Mitotic Cell Cycle Microtubule Bundle Formation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization	MAPK Cascade Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Migration Cell Migration Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway Caveola Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Podocyte Development Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Neuron Projection Extension
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Signaling by LTK in cancer	Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Artenimol
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 31178129) Body fat percentage and HDL-C (pairwise) ( 33619380) Body mass index ( 25673413 26961502) Body mass index and HDL-C (pairwise) ( 33619380) Chronotype ( 30696823) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Weight ( 28552196)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Chronic postoperative pain ( 31903573) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)
Interacting Genes		13 interacting genes: BIN1 CALM1 CLASP2 CLIP4 DCTN1 IQGAP1 MAPRE2 MTOR PAFAH1B1 REL TSC22D2 TUBA1A TUBB	45 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CDK1 CDK2 CEBPA CLIC5 CLIP1 CREBBP CTNNB1 CYBB DSCAM DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 LCOR MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 NRIP1 NUMB OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP
Entrez ID		6249	8826
HPRD ID		01568	04541
Ensembl ID		ENSG00000130779	ENSG00000140575
Uniprot IDs		B3KXA5 P30622	A0A0J9YXZ5 P46940
PDB IDs		2CP5 2CP6 2E3H 2E3I 2E4H 2HQH 2QK0 3E2U 3RDV 8WHH 8WHI	1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?		Microtubule Microtubule Plus-end Binding Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Cytoplasmic Microtubule Cell Leading Edge Cell Cortex Cell Division Microtubule Plus-end Microtubule-based Process Regulation Of Cytoskeleton Organization Neuromuscular Process Cytoskeleton Establishment Of Mitotic Spindle Localization Protein-containing Complex Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Epithelial Cell Migration Organelle Assembly Cellular Component Assembly Establishment Of Spindle Localization Cytoskeleton-dependent Intracellular Transport Spindle Localization Organelle Organization Organelle Localization Regulation Of Epithelial Cell Migration Spindle Positive Regulation Of Keratinocyte Migration Microtubule Binding Microtubule Organizing Center Organization Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Establishment Of Organelle Localization Spindle Assembly Establishment Of Localization In Cell Regulation Of Microtubule Polymerization Or Depolymerization Nuclear Membrane Disassembly Regulation Of Synapse Organization Membrane Disassembly Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cellular Component Organization Regulation Of Organelle Organization Response To Calcium Ion Mitotic Spindle Microtubule Anchoring Mitotic Cell Cycle Regulation Of Supramolecular Fiber Organization	Intracellular Signaling Cassette Cadherin Binding Focal Adhesion Positive Regulation Of Protein Localization Developmental Process Lamellipodium Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Organelle Organization Cellular Developmental Process Centrosome Intracellular Signal Transduction Glutamatergic Synapse Cell Development Neuron Fate Determination Cell Projection Cytoskeleton Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Protein Localization Cell Junction Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Cellular Localization Actin Cytoskeleton Adherens Junction Cytoplasm Adherens Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Phosphorylation Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Locomotion Regulation Of Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cytosol Cyclin-dependent Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Locomotion
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