ASCC3 and RNF26

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		ASCC3	RNF26
Description		activating signal cointegrator 1 complex subunit 3	ring finger protein 26
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Replication DNA Repair DNA Alkylation Repair Protein Monoubiquitination DNA Damage Response Ribosome Disassembly Protein Ufmylation Rescue Of Stalled Ribosome CAT Tailing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Anxiety ( 33859377) Depression ( 33859377) Economic and political preferences (immigration/crime) ( 22566634) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Putamen volume ( 29147026) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sub-cortical grey matter volume ( 31530798) Total cholesterol levels ( 33339817)	Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: APPBP2 ASCC1 FAXC PTEN RNF10 RNF26 RPS6KA1 SKIL TRIP4 UBC	55 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 VPS11 WRNIP1 YME1L1
Entrez ID		10973	79102
HPRD ID		09980	05842
Ensembl ID		ENSG00000112249	ENSG00000173456
Uniprot IDs		B4DR60 Q8N3C0	Q9BY78
PDB IDs		6YXQ 8ALZ
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Ubiquitination Proteolysis Protein Modification By Small Protein Conjugation Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell Differentiation Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Macromolecule Metabolic Process Regulation Of Neurogenesis Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process PML Body Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Nervous System Development RQC-trigger Complex Nucleoplasm Regulation Of Nervous System Process Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Nervous System Development Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Neurogenesis Positive Regulation Of Hepatic Stellate Cell Activation Catabolic Process Proteasomal Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Axonogenesis Regulation Of Synaptic Vesicle Clustering Ribosomal Protein S6 Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Hepatocyte Proliferation	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation
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