RNF26 and YME1L1

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		RNF26	YME1L1
Description		ring finger protein 26	YME1 like 1 ATPase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane Nuclear Body
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Mitochondrion Organization Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Mitochondrial Fusion Protein Hexamerization Mitochondrial Protein Processing Mitochondrial Protein Catabolic Process Negative Regulation Of Apoptotic Process Neuronal Stem Cell Population Maintenance Regulation Of Stem Cell Division
Pathways			Processing of SMDT1 Mitochondrial protein degradation Cellular response to mitochondrial stress
Drugs
Diseases
GWAS		Platelet count ( 32888494) Refractive error ( 32231278)	Shigella-associated diarrhea ( 33649051) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		55 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 VPS11 WRNIP1 YME1L1	7 interacting genes: BCL11A MYOG OGT PSEN1 PSMG1 RNF26 UBC
Entrez ID		79102	10730
HPRD ID		05842	06981
Ensembl ID		ENSG00000173456	ENSG00000136758
Uniprot IDs		Q9BY78	Q96TA2
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation	Cellular Response To Oxygen-containing Compound Protein Modification Process Regulation Of ATP Metabolic Process Negative Regulation Of Axonogenesis Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Negative Regulation Of Core Promoter Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Proteasome Core Complex Assembly Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Chromatin DNA Binding Nucleoplasm Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Developmental Process Protein Catabolic Process At Postsynapse Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Proteolysis Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Neuron Projection Development Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Neurogenesis Negative Regulation Of Protein-containing Complex Assembly Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Protein Homooligomerization Transcription Regulatory Region Nucleic Acid Binding Negative Regulation Of Neuron Maturation Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Axonogenesis Synaptic Vesicle Targeting Protein Glycosylation Negative Regulation Of Nervous System Development Negative Regulation Of Proteolysis Macromolecule Glycosylation Astrocyte Activation Involved In Immune Response Negative Regulation Of Dendrite Extension Negative Regulation Of Protein Oligomerization Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Sequestering Of Calcium Ion
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