ASCC3 and ASCC1

Number of citations of the paper that reports this interaction (PubMedID 12077347)
29

Data Source:
HPRD (two hybrid, in vivo)

		ASCC3	ASCC1
Description		activating signal cointegrator 1 complex subunit 3	activating signal cointegrator 1 complex subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex	Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Speck DNA Repair Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	RNA Binding Protein Binding
	Biological Process	DNA Replication DNA Repair DNA Alkylation Repair Protein Monoubiquitination DNA Damage Response Ribosome Disassembly Protein Ufmylation Rescue Of Stalled Ribosome CAT Tailing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response
Pathways		ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	ALKBH3 mediated reversal of alkylation damage
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Anxiety ( 33859377) Depression ( 33859377) Economic and political preferences (immigration/crime) ( 22566634) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Putamen volume ( 29147026) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sub-cortical grey matter volume ( 31530798) Total cholesterol levels ( 33339817)	Body mass index ( 30045251) Metabolite levels ( 23823483) Physiological traits ( 31902109)
Interacting Genes		10 interacting genes: APPBP2 ASCC1 FAXC PTEN RNF10 RNF26 RPS6KA1 SKIL TRIP4 UBC	6 interacting genes: ASCC3 NCOA6 OGT TRAF2 TRAF3 UBC
Entrez ID		10973	51008
HPRD ID		09980	12497
Ensembl ID		ENSG00000112249	ENSG00000138303
Uniprot IDs		B4DR60 Q8N3C0	A0A5F9ZH79 A0A5K1VW55 Q8N9N2
PDB IDs		6YXQ 8ALZ	8TLY
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Ubiquitination Proteolysis Protein Modification By Small Protein Conjugation Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell Differentiation Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Macromolecule Metabolic Process Regulation Of Neurogenesis Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process PML Body Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Nervous System Development RQC-trigger Complex Nucleoplasm Regulation Of Nervous System Process Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Nervous System Development Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Neurogenesis Positive Regulation Of Hepatic Stellate Cell Activation Catabolic Process Proteasomal Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Axonogenesis Regulation Of Synaptic Vesicle Clustering Ribosomal Protein S6 Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Hepatocyte Proliferation	Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor Receptor Binding Ubiquitin Protein Ligase Binding TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity TOR Signaling TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly Macromolecule Metabolic Process CD40 Receptor Binding Macromolecule Biosynthetic Process Protein Modification Process Response To Stress Protein Ubiquitination Cytosol Protein O-acetylglucosaminyltransferase Activity CAT Tailing RQC-trigger Complex Protein Modification By Small Protein Conjugation Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of DNA-binding Transcription Factor Activity CD27 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cytoplasmic Translational Elongation Post-translational Protein Modification Catabolic Process Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Apoptotic Process Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Carbon Catabolite Regulation Of Transcription Cell Death Programmed Cell Death Nucleoplasm Ubiquitin-protein Transferase Activity Regulation Of Transcription By Glucose Protein Ufmylation
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