CEBPE and ATF5

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CEBPE	ATF5
Description		CCAAT enhancer binding protein epsilon	activating transcription factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Cytoskeleton RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Tubulin Binding Kinase Binding Sequence-specific DNA Binding
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Defense Response Positive Regulation Of Gene Expression Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Integrated Stress Response Signaling	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Negative Regulation Of Cell Population Proliferation Post-embryonic Development Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Olfactory Bulb Interneuron Development Cerebellar Granule Cell Precursor Proliferation Olfactory Lobe Development Multicellular Organism Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centrosome Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Transcriptional regulation of granulopoiesis	Response of EIF2AK1 (HRI) to heme deficiency Mitochondrial unfolded protein response (UPRmt) Mitochondrial unfolded protein response (UPRmt)
Drugs			Pseudoephedrine
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 29348612 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010 28158719 27863252)
Interacting Genes		45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384	18 interacting genes: ATXN1 CCDC6 CCND3 CDC34 CEBPA CEBPE CEBPG DISC1 EIF2B1 EP300 FBXO7 GABBR1 GABBR2 GIT2 GPS2 KEAP1 SYCE1L TTR
Entrez ID		1053	22809
HPRD ID		02852	05906
Ensembl ID		ENSG00000092067	ENSG00000169136
Uniprot IDs		Q15744	Q9Y2D1
PDB IDs		3T92
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-binding Transcription Factor Binding	Mononuclear Cell Differentiation G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Leukocyte Differentiation GABA Receptor Complex Integrated Stress Response Signaling Neuron-glial Cell Signaling GABA Receptor Activity Identical Protein Binding STAT Family Protein Binding DNA-templated Transcription Lymphocyte Activation Protein-containing Complex Myeloid Cell Differentiation Lymphocyte Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Leukocyte Activation Signal Transduction B Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Gamma-aminobutyric Acid Signaling Pathway Protein Heterodimerization Activity Granulocyte Differentiation Protein-containing Complex Binding Cell Activation Synaptic Transmission, GABAergic Nucleoplasm Regulation Of Cell Differentiation Macrophage Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding B Cell Activation Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite
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