CEBPE and CSNK1A1L

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CEBPE	CSNK1A1L
Description		CCAAT enhancer binding protein epsilon	casein kinase 1 alpha 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Defense Response Positive Regulation Of Gene Expression Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Integrated Stress Response Signaling	Signal Transduction Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Transcriptional regulation of granulopoiesis
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 29348612 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010 28158719 27863252)	Adiponectin levels in pregnancy ( 28317342) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Palmitoleic acid (16:1n-7) levels ( 23362303)
Interacting Genes		45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384	5 interacting genes: CEACAM3 CEBPE JAM2 TNFRSF1A TNFRSF1B
Entrez ID		1053	122011
HPRD ID		02852	13095
Ensembl ID		ENSG00000092067	ENSG00000180138
Uniprot IDs		Q15744	Q8N752
PDB IDs		3T92
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-binding Transcription Factor Binding	Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Apoptotic Process Involved In Morphogenesis Aortic Valve Development Tumor Necrosis Factor Binding Semi-lunar Valve Development Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Tumor Necrosis Factor Receptor Activity Heart Valve Development Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Specific Granule Membrane Regulation Of System Process Extrinsic Apoptotic Signaling Pathway Regulation Of Nervous System Process Cell Surface Negative Regulation Of Secretion By Cell Cellular Response To Lipopolysaccharide Negative Regulation Of Secretion Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Glial Cell-neuron Signaling Cellular Response To Molecule Of Bacterial Origin Plasma Membrane Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Lymphocyte Aggregation Membrane Raft Regulation Of Muscle System Process Hematopoietic Stem Cell Migration Negative Regulation Of Defense Response Negative Regulation Of Myelination Negative Regulation Of Multicellular Organismal Process Response To Lipopolysaccharide Leukocyte Aggregation Apoptotic Signaling Pathway Response To Molecule Of Bacterial Origin Response To External Biotic Stimulus Defense Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Membrane Protein Ectodomain Proteolysis DNA-templated Transcription
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