GPNMB and GSDME

		GPNMB	GSDME
Description		glycoprotein nmb	gasdermin E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Melanosome Membrane	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding
	Biological Process	Negative Regulation Of Cytokine Production Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PTK6 promotes HIF1A stabilization	Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs		Glembatumumab vedotin
Diseases			Deafness, autosomal dominant
GWAS		Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		5 interacting genes: EGFR GSDME ITSN2 LINC01139 SMAD4	13 interacting genes: AHR C1GALT1 CFTR GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41 WEE2-AS1
Entrez ID		10457	1687
HPRD ID		05081	02996
Ensembl ID		ENSG00000136235	ENSG00000105928
Uniprot IDs		Q14956 Q96F58	A4FVA8 O60443
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiocyte Differentiation Intracellular Vesicle Regulation Of Cell Growth Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Regulation Of MAPK Cascade Regulation Of Growth Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epidermal Growth Factor Binding Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Protein Kinase C Signaling Sulfate Binding Endocardial Cell Differentiation Wide Pore Channel Activity Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Growth ERBB2-EGFR Signaling Pathway MAPK Cascade SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Brainstem Development Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Tube Morphogenesis Regulation Of ERK1 And ERK2 Cascade	Cellular Response To Forskolin Response To Forskolin
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