GSDME

Description		gasdermin E
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding
	Biological Process	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs
Diseases		Deafness, autosomal dominant
GWAS
Novel Interacting Genes		13 novel interacting genes: AHR C1GALT1 CFTR GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41 WEE2-AS1
Interacting Genes		13 interacting genes: AHR C1GALT1 CFTR GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41 WEE2-AS1
Entrez ID		1687
HPRD ID		02996
Ensembl ID		ENSG00000105928
Uniprot IDs		A4FVA8 O60443
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Forskolin Response To Forskolin
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