GSDME and GP1BB

		GSDME	GP1BB
Description		gasdermin E	glycoprotein Ib platelet subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Plasma Membrane Membrane Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs
Diseases		Deafness, autosomal dominant	Bernard-Soulier syndrome; Giant platelet syndrome
GWAS			DNA methylation (parent-of-origin) ( 23725790) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		13 interacting genes: AHR C1GALT1 CFTR GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41 WEE2-AS1	5 interacting genes: GP9 GSDME PRKACA TGFB1I1 YWHAZ
Entrez ID		1687	2812
HPRD ID		02996	00729
Ensembl ID		ENSG00000105928	ENSG00000203618
Uniprot IDs		A4FVA8 O60443	P13224
PDB IDs			3REZ 3RFE 8WFS
Enriched GO Terms of Interacting Partners?		Cellular Response To Forskolin Response To Forskolin	Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Sequestering Of Calcium Ion Tube Formation Synaptic Target Recognition Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Cell Communication Inner Ear Receptor Cell Differentiation Regulation Of Signal Transduction Mechanoreceptor Differentiation Positive Regulation Of Immune Response To Tumor Cell Cellular Developmental Process Pyroptotic Cell Death Wide Pore Channel Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Epithelial Cell Differentiation Regulation Of Signaling Developmental Process System Process Protein Activation Cascade Glycoprotein Ib-IX-V Complex Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Megakaryocyte Development Regulation Of Body Fluid Levels CAMP-dependent Protein Kinase Complex Protein-lipid Complex Assembly Vascular Endothelial Cell Response To Fluid Shear Stress Response To Nutrient Levels Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Glucagon Stimulus Ubiquitin Protein Ligase Binding Negative Regulation Of Interleukin-2 Production Response To Laminar Fluid Shear Stress Sperm Capacitation Protein Domain Specific Binding CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Protein Phosphorylation Calcium Channel Complex Regulation Of Proteolysis Cellular Response To Laminar Fluid Shear Stress
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