EMG1 and ZCCHC9

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EMG1	ZCCHC9
Description		EMG1 N1-specific pseudouridine methyltransferase	zinc finger CCHC-type containing 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Small-subunit Processome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity Transferase Activity RRNA Binding Identical Protein Binding RRNA (pseudouridine) Methyltransferase Activity	Nucleic Acid Binding RNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Blastocyst Development RRNA Processing Nucleologenesis Methylation Ribosome Biogenesis Ribosomal Small Subunit Biogenesis RRNA Base Methylation
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Bowen-Conradi syndrome (BCS)
GWAS
Interacting Genes		20 interacting genes: ANXA3 APP CEBPA CFTR CTSE FAM74A4 FAM98A HIVEP1 HSD3B7 IL7R KHDRBS1 MCPH1 NAA80 PRC1 PSMB7 PSME1 SLC25A38 SUMO2 ZCCHC9 ZNF768	4 interacting genes: EMG1 FAM98A SSBP2 UBTFL1
Entrez ID		10436	84240
HPRD ID		12803	15704
Ensembl ID		ENSG00000126749	ENSG00000131732
Uniprot IDs		Q92979	Q8N567
PDB IDs		5FAI 7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?			RRNA (pseudouridine) Methyltransferase Activity Macromolecule Methylation Nucleologenesis RRNA Base Methylation Nucleolus Organization RNA Metabolic Process Methylation TRNA-splicing Ligase Complex RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Blastocyst Growth RNA Polymerase I Preinitiation Complex Assembly TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Protein Methyltransferase Activity Positive Regulation Of Ruffle Assembly Transcription By RNA Polymerase I RRNA Methylation Nucleic Acid Metabolic Process Blastocyst Development Regulation Of Ruffle Assembly Positive Regulation Of Transcription By RNA Polymerase I RRNA Modification Protein Methylation RRNA Binding Regulation Of Transcription By RNA Polymerase I Embryo Implantation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
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