WFDC2 and PLS3

		WFDC2	PLS3
Description		WAP four-disulfide core domain 2	plastin 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton
	Biological Process	Proteolysis Spermatogenesis Antibacterial Humoral Response Innate Immune Response	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization
Pathways		Formation of the nephric duct
Drugs
Diseases
GWAS		Brain structure ( 20171287)	Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)
Interacting Genes		17 interacting genes: ARL13B CD40 CD79A COQ9 CPLX4 CREB3L1 CYB5R3 FAM209A FKBP7 GORAB LMNA PANX1 PLS3 PTN SLC22A23 STOM TMX2	19 interacting genes: ACRV1 APP ASGR1 ATXN2 CUL4B CXCR5 FILNC1 FRYL LRCH2 NRSN1 OGT PTPN5 SNCA TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195
Entrez ID		10406	5358
HPRD ID		11684	02133
Ensembl ID		ENSG00000101443	ENSG00000102024
Uniprot IDs		A0A384MTN6 Q14508	B4DPW9 P13797
PDB IDs			1AOA 1WJO 7R94 7SX8 7SX9 7SXA
Enriched GO Terms of Interacting Partners?			Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation
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