PLS3 and TRPC5

		PLS3	TRPC5
Description		plastin 3	transient receptor potential cation channel subfamily C member 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle	Plasma Membrane Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Presynapse
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton	Actin Binding Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Neuron Differentiation Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Membrane Hyperpolarization
Pathways			TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)	Smoking behavior ( 19247474)
Interacting Genes		19 interacting genes: ACRV1 APP ASGR1 ATXN2 CUL4B CXCR5 FILNC1 FRYL LRCH2 NRSN1 OGT PTPN5 SNCA TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195	10 interacting genes: DRD2 ENKUR ITPR3 MX1 NHERF1 PLS3 STMN2 STMN3 TRPC1 TRPC4
Entrez ID		5358	7224
HPRD ID		02133	02273
Ensembl ID		ENSG00000102024	ENSG00000072315
Uniprot IDs		B4DPW9 P13797	Q9UL62
PDB IDs		1AOA 1WJO 7R94 7SX8 7SX9 7SXA	6YSN 7D4P 7D4Q 7E4T 7WDB 7X6C 7X6I 8GVW 8GVX
Enriched GO Terms of Interacting Partners?		Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation	Inositol 1,4,5 Trisphosphate Binding Acid Secretion Inorganic Ion Homeostasis Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Calcium Ion Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Metal Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Gamma-aminobutyric Acid Transport Monoatomic Cation Transport Cation Channel Complex Microtubule Depolymerization Regulation Of Sequestering Of Calcium Ion Chemical Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Ion Channel Activity Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Intracellular Chemical Homeostasis Protein Depolymerization Microtubule Polymerization Or Depolymerization Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Cellular Homeostasis Carboxylic Acid Transport Organic Acid Transport Homeostatic Process Inorganic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Structural Constituent Of Presynaptic Actin Cytoskeleton Renal Phosphate Ion Absorption Tubulin Binding Monoatomic Ion Transmembrane Transport Regulation Of Sodium Ion Transport Response To Metal Ion Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Organic Anion Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Phenol-containing Compound Metabolic Process Apical Part Of Cell
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