NDRG1 and MAOA

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		NDRG1	MAOA
Description		N-myc downstream regulated 1	monoamine oxidase A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane
	Molecular Function	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	Protein Binding Primary Methylamine Oxidase Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding Monoamine Oxidase Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia	Biogenic Amine Metabolic Process Catecholamine Metabolic Process Positive Regulation Of Signal Transduction Dopamine Catabolic Process
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Norepinephrine Neurotransmitter Release Cycle Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Dopamine clearance from the synaptic cleft Metabolism of serotonin Defective MAOA causes BRUNS Interleukin-4 and Interleukin-13 signaling
Drugs			Amphetamine Phentermine Procaine Tranylcypromine Phenelzine Minaprine Zonisamide Selegiline Procarbazine Moclobemide Moclobemide Isocarboxazid Ephedra sinica root Ginkgo biloba MMDA 4-Methoxyamphetamine Metamfetamine Pargyline Flavin adenine dinucleotide Clorgiline Nialamide Nomifensine Zimelidine Posizolid CX157 Decyl(dimethyl)phosphine oxide Harmine Viloxazine Pirlindole Toloxatone Brofaromine Flortaucipir F-18
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Brunner syndrome; MAOA deficiency
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Smoking behavior ( 19247474)
Interacting Genes		73 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GPAA1 GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TFAP2B TLE3 UPF1 VCP XRCC5 ZNF155	1 interacting genes: NDRG1
Entrez ID		10397	4128
HPRD ID		05586	02400
Ensembl ID		ENSG00000104419	ENSG00000189221
Uniprot IDs		Q8N959 Q92597	P21397 Q49A63 Q53YE7
PDB IDs		6ZMM	2BXR 2BXS 2Z5X 2Z5Y
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression	Mast Cell Activation Nickel Cation Binding Peripheral Nervous System Myelin Maintenance Myelin Maintenance Gamma-tubulin Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction By P53 Class Mediator Cellular Response To Oxygen Levels Signal Transduction In Response To DNA Damage Recycling Endosome Membrane Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Myeloid Leukocyte Activation Plasma Membrane Organization Adherens Junction
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