MAOA

Description		monoamine oxidase A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane
	Molecular Function	Protein Binding Primary Methylamine Oxidase Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding Monoamine Oxidase Activity
	Biological Process	Biogenic Amine Metabolic Process Catecholamine Metabolic Process Positive Regulation Of Signal Transduction Dopamine Catabolic Process
Pathways		Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Norepinephrine Neurotransmitter Release Cycle Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Dopamine clearance from the synaptic cleft Metabolism of serotonin Defective MAOA causes BRUNS Interleukin-4 and Interleukin-13 signaling
Drugs		Amphetamine Phentermine Procaine Tranylcypromine Phenelzine Minaprine Zonisamide Selegiline Procarbazine Moclobemide Moclobemide Isocarboxazid Ephedra sinica root Ginkgo biloba MMDA 4-Methoxyamphetamine Metamfetamine Pargyline Flavin adenine dinucleotide Clorgiline Nialamide Nomifensine Zimelidine Posizolid CX157 Decyl(dimethyl)phosphine oxide Harmine Viloxazine Pirlindole Toloxatone Brofaromine Flortaucipir F-18
Diseases		Brunner syndrome; MAOA deficiency
GWAS		Smoking behavior ( 19247474)
Novel Interacting Genes		1 novel interacting genes: NDRG1
Interacting Genes		1 interacting genes: NDRG1
Entrez ID		4128
HPRD ID		02400
Ensembl ID		ENSG00000189221
Uniprot IDs		P21397 Q49A63 Q53YE7
PDB IDs		2BXR 2BXS 2Z5X 2Z5Y
Enriched GO Terms of Interacting Partners?		Mast Cell Activation Nickel Cation Binding Peripheral Nervous System Myelin Maintenance Myelin Maintenance Gamma-tubulin Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction By P53 Class Mediator Cellular Response To Oxygen Levels Signal Transduction In Response To DNA Damage Recycling Endosome Membrane Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Myeloid Leukocyte Activation Plasma Membrane Organization Adherens Junction
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