NDRG1 and FASN

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		NDRG1	FASN
Description		N-myc downstream regulated 1	fatty acid synthase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	RNA Binding Catalytic Activity Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Protein Binding Fatty Acyl-[ACP] Hydrolase Activity Oxidoreductase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lyase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia	Osteoblast Differentiation Epithelial Cell Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Response To Nutrient Lipid Biosynthetic Process Ether Lipid Biosynthetic Process Tissue Development Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Response To Nutrient Levels Host-mediated Perturbation Of Viral Process Fatty-acyl-CoA Biosynthetic Process Response To Caloric Restriction Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs			Cerulenin Orlistat
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)
Interacting Genes		73 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GPAA1 GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TFAP2B TLE3 UPF1 VCP XRCC5 ZNF155	18 interacting genes: ADIPOQ AKT1 ASXL1 BIRC5 CEBPA CRYAA DUX4 EWSR1 HSP90AA1 LNX1 MTDH NDRG1 PRR12 PTEN RPF1 SNX8 SUMO2 YWHAQ
Entrez ID		10397	2194
HPRD ID		05586	02567
Ensembl ID		ENSG00000104419	ENSG00000169710
Uniprot IDs		Q8N959 Q92597	P49327
PDB IDs		6ZMM	1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA 7MHD 7MHE 8EYI 8EYK 8G7X 8GKC 8VF7 8VG4 8VLE 8VLO 8VLP 8VM0 8VM5 8VM6 8VM7 8VMC 8VMD 9B7Z 9B80 9MJ9
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression	Identical Protein Binding Myelin Maintenance Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Fat Cell Differentiation Positive Regulation Of Catabolic Process Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteolysis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Nucleus Regulation Of Gene Expression Response To Heat Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Synapse Maturation Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Proteasomal Protein Catabolic Process Plasma Membrane Organization Response To Decreased Oxygen Levels Programmed Cell Death Response To Tumor Necrosis Factor Cell Death Response To Oxygen Levels Protein Refolding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Peptidyl-serine Phosphorylation Reactive Nitrogen Species Metabolic Process Response To Temperature Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation 14-3-3 Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Brown Fat Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Homodimerization Activity
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