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STUB1 and ATXN3
Number of citations of the paper that reports this interaction (PubMedID
32401531
)
36
Data Source:
BioGRID
(enzymatic study)
STUB1
ATXN3
Description
STIP1 homology and U-box containing protein 1
ataxin 3
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Protein Folding Chaperone Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Matrix
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Membrane
Nuclear Matrix
Mitochondrial Membrane
Nuclear Inclusion Body
Synapse
Molecular Function
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
R-SMAD Binding
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
ATPase Binding
K63-linked Deubiquitinase Activity
K48-linked Deubiquitinase Activity
Biological Process
MAPK Cascade
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
DNA Damage Response
Signal Transduction
Positive Regulation Of Metabolic Process
Negative Regulation Of Cardiac Muscle Hypertrophy
Protein Ubiquitination
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Cellular Response To Heat
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
ERAD Pathway
ERBB2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Protein Stabilization
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Mitophagy
Positive Regulation Of ERAD Pathway
Negative Regulation Of Vascular Associated Smooth Muscle Contraction
Microtubule Cytoskeleton Organization
Cytoplasmic Translation
Nucleotide-excision Repair
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Chemical Synaptic Transmission
Nervous System Development
Cellular Response To Starvation
Regulation Of Cell-substrate Adhesion
Protein Deubiquitination
Actin Cytoskeleton Organization
Cellular Response To Nutrient Levels
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Monoubiquitinated Protein Deubiquitination
Exploration Behavior
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Misfolded Protein
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Josephin domain DUBs
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Amyotrophic lateral sclerosis (
29566793
)
Coronary artery calcification (
23870195
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Height (
18391950
18391951
)
Hip circumference adjusted for BMI (
34021172
)
LDL cholesterol levels x loop diuretics use interaction (
31806883
)
Orofacial clefts (
22419666
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
149 interacting genes:
ABL1
ACD
ADRM1
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BBOX1
BCR
BMPR1B
CASP6
CCL28
CDK4
CDK9
CDKN1A
CFTR
CIP2A
CRIP1
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EGFR
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FXR1
GHR
GPR37
GUCY1A1
GUCY1A2
HMGB1
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
HUNK
INSR
JAK1
JOSD1
JOSD2
KHDRBS1
KPNA2
LRRK1
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
METTL14
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
OTUD3
PA2G4
PFN1
PKM
PLK1
PMAIP1
POLB
POT1
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PSMA3
PSMC2
PSMD1
PSMD2
PSMD4
RAF1
RFFL
RGS17
RHBDF2
RUNX1
RUNX2
RUSC1
S100A2
S100P
SIRT6
SLC7A11-AS1
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNCA
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TP53
TP63
TP73
TPD52
TRAF6
TTN
TXN2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
UNC45B
VCP
VDAC1
XIAP
YTHDF2
55 interacting genes:
ANXA7
APP
ARHGAP19
ARHGDIA
ASIC1
CAPN1
CAPN2
CASP1
CDKN1A
CHEK1
CSNK2B
DNM2
EWSR1
GABARAP
GSK3B
KAT2B
KPNA2
MAP1LC3A
MAP1LC3C
MAP3K1
MKNK1
NCOR1
NEDD8
PHAF1
PICK1
PRKN
PSMD7
RAD23A
RAD23B
RFFL
RPS6KA1
SMURF1
SQSTM1
STUB1
SUMO1
TEX11
TK1
TP53
TRAF6
TRIM54
TRIM55
TRIM63
TUBA1A
TUBB
UBB
UBC
UBE2D3
UBE2L3
UBE2S
UBE2W
UBE4B
UBQLN1
USP21
VCP
WWP2
Entrez ID
10273
4287
HPRD ID
06232
06131
Ensembl ID
ENSG00000103266
ENSG00000066427
Uniprot IDs
Q9UNE7
A0A0A0MS38
C9JQV6
P54252
PDB IDs
4KBQ
6EFK
6NSV
7TB1
8EHZ
8EI0
8F14
8F15
8F16
8F17
8FYU
8GCK
8SUV
9DRY
1YZB
2AGA
2DOS
2JRI
2KLZ
4WTH
4YS9
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Binding
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Ubiquitin Conjugating Enzyme Activity
Intracellular Signal Transduction
Cytosol
Regulation Of Primary Metabolic Process
Enzyme Binding
Positive Regulation Of Macromolecule Metabolic Process
ATP Binding
Nucleus
Cytoplasm
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Protein Modification Process
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Intracellular Signal Transduction
Protein-containing Complex
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Post-translational Protein Modification
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Post-translational Protein Modification
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Stress
Cellular Response To Stress
Proteasomal Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Modification Process
Protein Metabolic Process
Macromolecule Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Cytosol
Post-translational Protein Modification
Cytoplasm
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Catabolic Process
Regulation Of Proteolysis
Macromolecule Metabolic Process
Protein Polyubiquitination
Positive Regulation Of Post-translational Protein Modification
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Cellular Response To Stress
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Autophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Enzyme Binding
Protein K63-linked Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Response To Stress
Ubiquitin Protein Ligase Activity
Nucleus
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Mitophagy
Macroautophagy
Regulation Of Programmed Cell Death
Protein Autoubiquitination
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Tagcloud (Intersection)
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