STUB1 and GUCY1A1

Number of citations of the paper that reports this interaction (PubMedID 17873020)
0

Data Source:
HPRD (in vivo)

		STUB1	GUCY1A1
Description		STIP1 homology and U-box containing protein 1	guanylate cyclase 1 soluble subunit alpha 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Protein Folding Chaperone Complex	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity R-SMAD Binding	Nucleotide Binding Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway ERAD Pathway ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Mitophagy Positive Regulation Of ERAD Pathway Negative Regulation Of Vascular Associated Smooth Muscle Contraction	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction CGMP-mediated Signaling Intracellular Signal Transduction Nitric Oxide-cGMP-mediated Signaling Relaxation Of Vascular Associated Smooth Muscle Response To Oxygen Levels Retrograde Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission
Pathways		Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction
Drugs			Isosorbide
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Appendicular lean mass ( 33097823)
Interacting Genes		149 interacting genes: ABL1 ACD ADRM1 AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BBOX1 BCR BMPR1B CASP6 CCL28 CDK4 CDK9 CDKN1A CFTR CIP2A CRIP1 CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EGFR EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FXR1 GHR GPR37 GUCY1A1 GUCY1A2 HMGB1 HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 HUNK INSR JAK1 JOSD1 JOSD2 KHDRBS1 KPNA2 LRRK1 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 METTL14 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 OTUD3 PA2G4 PFN1 PKM PLK1 PMAIP1 POLB POT1 PPP3CA PRKACA PRKCZ PRKN PRMT1 PSMA3 PSMC2 PSMD1 PSMD2 PSMD4 RAF1 RFFL RGS17 RHBDF2 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SLC7A11-AS1 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNCA SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TP53 TP63 TP73 TPD52 TRAF6 TTN TXN2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W UNC45B VCP VDAC1 XIAP YTHDF2	4 interacting genes: AGAP1 IKBKG MAPK8 STUB1
Entrez ID		10273	2982
HPRD ID		06232	00768
Ensembl ID		ENSG00000103266	ENSG00000164116
Uniprot IDs		Q9UNE7	B3KU69 Q02108
PDB IDs		4KBQ 6EFK 6NSV 7TB1 8EHZ 8EI0 8F14 8F15 8F16 8F17 8FYU 8GCK 8SUV 9DRY	3UVJ 4NI2 6JT0 6JT1 6JT2 7D9R 7D9S 7D9T 7D9U 8HBE 8HBF 8HBH
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Intracellular Signal Transduction Cytosol Regulation Of Primary Metabolic Process Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Nucleus Cytoplasm Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleotide Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Cellular Response To Stress Proteasomal Protein Catabolic Process	Regulation Of Macroautophagy Regulation Of Autophagy JUN Phosphorylation Positive Regulation Of Catabolic Process Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly DNA Damage Response Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process JUN Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Linear Polyubiquitin Binding Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteolysis Ubiquitin Conjugating Enzyme Complex Histone Deacetylase Regulator Activity Basal Dendrite MAPK Cascade Postsynaptic Endosome Immune Response-regulating Cell Surface Receptor Signaling Pathway IkappaB Kinase Complex Chaperone-mediated Autophagy Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin Protein Ligase Binding TPR Domain Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To Stress Regulation Of Protein Metabolic Process Transferrin Receptor Binding Regulation Of Proteolysis Anoikis Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Regulation Of Vascular Associated Smooth Muscle Contraction Cellular Response To Misfolded Protein Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Vasoconstriction Response To Misfolded Protein Enzyme Binding Immune Response-regulating Signaling Pathway Regulation Of Protein-containing Complex Assembly
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