GUCY1A1

Description		guanylate cyclase 1 soluble subunit alpha 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding Signaling Receptor Activity
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction CGMP-mediated Signaling Intracellular Signal Transduction Nitric Oxide-cGMP-mediated Signaling Relaxation Of Vascular Associated Smooth Muscle Response To Oxygen Levels Retrograde Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction
Drugs		Isosorbide
Diseases
GWAS		Appendicular lean mass ( 33097823)
Novel Interacting Genes		4 novel interacting genes: AGAP1 IKBKG MAPK8 STUB1
Interacting Genes		4 interacting genes: AGAP1 IKBKG MAPK8 STUB1
Entrez ID		2982
HPRD ID		00768
Ensembl ID		ENSG00000164116
Uniprot IDs		B3KU69 Q02108
PDB IDs		3UVJ 4NI2 6JT0 6JT1 6JT2 7D9R 7D9S 7D9T 7D9U 8HBE 8HBF 8HBH
Enriched GO Terms of Interacting Partners?		Regulation Of Macroautophagy Regulation Of Autophagy JUN Phosphorylation Positive Regulation Of Catabolic Process Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly DNA Damage Response Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process JUN Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Linear Polyubiquitin Binding Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteolysis Ubiquitin Conjugating Enzyme Complex Histone Deacetylase Regulator Activity Basal Dendrite MAPK Cascade Postsynaptic Endosome Immune Response-regulating Cell Surface Receptor Signaling Pathway IkappaB Kinase Complex Chaperone-mediated Autophagy Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin Protein Ligase Binding TPR Domain Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To Stress Regulation Of Protein Metabolic Process Transferrin Receptor Binding Regulation Of Proteolysis Anoikis Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Regulation Of Vascular Associated Smooth Muscle Contraction Cellular Response To Misfolded Protein Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Vasoconstriction Response To Misfolded Protein Enzyme Binding Immune Response-regulating Signaling Pathway Regulation Of Protein-containing Complex Assembly
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