SPRY3 and LCE3E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPRY3	LCE3E
Description		sprouty RTK signaling antagonist 3	late cornified envelope 3E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Nervous System Development Regulation Of Signal Transduction Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Projection Arborization	Epidermis Development Keratinization
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Common traits (Other) ( 20585627) Inflammatory skin disease ( 25574825) Plantar warts ( 28928442) Psoriasis ( 25854761)
Interacting Genes		27 interacting genes: AQP1 BEX2 CATSPER1 CHRD CREB5 GNE GPSM3 HOXA1 HR KPRP KRT34 LCE1A LCE1B LCE1F LCE2B LCE3A LCE3D LCE3E MAPKBP1 MEOX2 NEK6 R3HDM2 SLC39A7 VSNL1 ZDHHC17 ZNF587 ZNF655	59 interacting genes: ADAMTSL4 ALPP CHIC2 CYSRT1 EFEMP2 GRN GSC2 HOXA1 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE2A MACO1 MDFI NBPF19 NOTCH2NLA NXF1 PLSCR2 RGS17 RGS20 SPRY1 SPRY2 SPRY3 TRIM42 VWC2
Entrez ID		10251	353145
HPRD ID		03917	13975
Ensembl ID		ENSG00000168939	ENSG00000185966
Uniprot IDs		O43610 Q6ZUP3	Q5T5B0
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Tissue Development	Intermediate Filament Keratin Filament Hair Cycle Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Epidermis Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation Protein Binding Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Branch Elongation Of An Epithelium Structural Constituent Of Skin Epidermis Negative Regulation Of Small GTPase Mediated Signal Transduction
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