LCE3E and TRIM42

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE3E	TRIM42
Description		late cornified envelope 3E	tripartite motif containing 42
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Epidermis Development Keratinization	Protein Ubiquitination
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Common traits (Other) ( 20585627) Inflammatory skin disease ( 25574825) Plantar warts ( 28928442) Psoriasis ( 25854761)	Bipolar disorder (body mass index interaction) ( 24322204) Refractive astigmatism ( 25367360)
Interacting Genes		59 interacting genes: ADAMTSL4 ALPP CHIC2 CYSRT1 EFEMP2 GRN GSC2 HOXA1 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE2A MACO1 MDFI NBPF19 NOTCH2NLA NXF1 PLSCR2 RGS17 RGS20 SPRY1 SPRY2 SPRY3 TRIM42 VWC2	147 interacting genes: ADAMTSL4 AIRIM AQP1 ARMC7 ARNT2 ARRDC3 ATG9A AXIN1 BACH2 BEX2 CARD9 CATSPER1 CBY2 CCDC120 CCDC24 CCDC33 CDCA7L CEP70 CERK CHCHD2 CHRD CREB5 CYSRT1 EFEMP2 EFHC2 EMD FAM124B FAM90A1 FBLN1 FCHO1 FNDC3B GLI1 GLRX3 GLYCTK GNE GOLGA2 GUCD1 HOXA1 HOXC8 HSD3B7 IGFN1 IHO1 IKZF3 IL16 IQUB KCTD9 KLHL38 KPRP KRT13 KRT15 KRT34 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-6 KRTAP5-7 KRTAP9-3 L3MBTL2 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 LONRF1 LZTS2 MAGOHB MAPKBP1 MEIS2 MEOX2 MFAP1 MGAT5B MID2 MTUS2 MVP NBPF19 NEK8 NOTCH2NLA NUFIP2 OTX1 PCSK5 PHLDA1 PLSCR1 PLSCR4 PNMA1 POU4F2 PRKAB2 PROP1 PSMA1 PSMD9 PTGER3 R3HDM2 RAMAC RCOR3 RUNX1T1 SCNM1 SHFL SLIT1 SMARCC1 SMCP SPAG8 SSX2IP STK16 TASOR2 TCAF1 TFAP2D TLX3 TMEM150A TRAF1 TRAF2 TRAPPC2B TRIM23 TRIM27 TXNDC5 VGLL3 VPS37A VWC2L YIPF3 YWHAQ YY1 ZBTB1 ZNF330 ZNF414
Entrez ID		353145	287015
HPRD ID		13975	15559
Ensembl ID		ENSG00000185966	ENSG00000155890
Uniprot IDs		Q5T5B0	Q8IWZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Epidermis Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation Protein Binding Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Branch Elongation Of An Epithelium Structural Constituent Of Skin Epidermis Negative Regulation Of Small GTPase Mediated Signal Transduction	Intermediate Filament Keratin Filament Epidermis Development Keratinization Protein Binding Tissue Development Identical Protein Binding CD4 Receptor Binding Hair Cycle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?