SORBS3 and VARS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SORBS3	VARS2
Description		sorbin and SH3 domain containing 3	valyl-tRNA synthetase 2, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction	Mitochondrion Cytosol
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Valine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Translation TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways		Smooth Muscle Contraction	Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Conotruncal heart defects (maternal effects) ( 28468790) Gestational age at birth (maternal effect) ( 28877031) HIV-1 control ( 20041166) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 20848476) Urate levels ( 31578528)
Interacting Genes		138 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 PPP3CC QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	8 interacting genes: ABI1 ABI2 ABI3 CMTM5 MAL2 NCK2 PIK3CA SORBS3
Entrez ID		10174	57176
HPRD ID		11535	11670
Ensembl ID		ENSG00000120896	ENSG00000137411
Uniprot IDs		O60504	A0A1U9X9B3 B4DG77 B4E0K6 Q5ST30
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection	Actin-based Cell Projection SCAR Complex Signaling Adaptor Activity Regulation Of Lamellipodium Assembly Lamellipodium Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Migration Filopodium Tip Neuron Migration Cell Motility Cytoskeletal Anchor Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Dendritic Spine Morphogenesis Postsynaptic Density Actin Filament Organization Lamellipodium Organization Cell Projection Morphogenesis Peptidyl-tyrosine Phosphorylation Actin Polymerization Or Depolymerization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Filopodium Cytoskeleton Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Zonula Adherens Assembly Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization SH3 Domain Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Organelle Organization Response To Butyrate Cellular Response To Hydrostatic Pressure Regulation Of Actin Polymerization Or Depolymerization Phosphatidylinositol 3-kinase Complex, Class IB Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Regulation Of Postsynapse Organization Regulation Of Actin Filament Length Dendritic Spine
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