SORBS3 and SOCS7

Number of citations of the paper that reports this interaction (PubMedID 15242778)
0

Data Source:
HPRD (in vivo, two hybrid)

		SORBS3	SOCS7
Description		sorbin and SH3 domain containing 3	suppressor of cytokine signaling 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding	Protein Binding SH3 Domain Binding Signaling Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Layer Formation In Cerebral Cortex Intracellular Signal Transduction Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Migration
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Ovarian cancer ( 23535730)
Interacting Genes		138 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 PPP3CC QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	25 interacting genes: CYSRT1 DAB1 EGFR EXOSC8 GAS2L2 GRB2 HSPB8 IRS2 IRS4 LENG8 MDFI MISP NCK1 NSMF OSTF1 PIK3R1 PIK3R2 PLCG1 SH3RF1 SORBS2 SORBS3 TNS2 TUBA1A TUBB4B YES1
Entrez ID		10174	30837
HPRD ID		11535	12299
Ensembl ID		ENSG00000120896	ENSG00000274211
Uniprot IDs		O60504	A0A5F9YLF9 O14512
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Insulin Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphatase Binding Phosphotyrosine Residue Binding Focal Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Cytoskeletal Anchor Activity Insulin Receptor Binding Cell Surface Receptor Signaling Pathway Cytoplasm Structural Constituent Of Cytoskeleton Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Intracellular Signaling Cassette Natural Killer Cell Mediated Cytotoxicity Regulation Of MAPK Cascade 1-phosphatidylinositol-3-kinase Regulator Activity Natural Killer Cell Mediated Immunity Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase Activator Activity Regulation Of Protein Localization To Cell Periphery Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Insulin Receptor Substrate Binding Leukocyte Mediated Cytotoxicity Regulation Of D-glucose Transmembrane Transport ERBB Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Signaling Adaptor Activity Anchoring Junction Actin Filament Intracellular Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Regulation Of Signaling Cytoskeleton Organization Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Motility
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