OCLN and ULK1

Number of citations of the paper that reports this interaction (PubMedID 16616143)
0

Data Source:
BioGRID (two hybrid)

		OCLN	ULK1
Description		occludin	unc-51 like autophagy activating kinase 1
Image
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction Anchoring Junction	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Phagophore Assembly Site Membrane Recycling Endosome Omegasome Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Epithelial Cell Migration Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of D-glucose Import Protein-containing Complex Assembly Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Tight Junction Organization Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability	Autophagosome Assembly Mitophagy Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Signal Transduction Axonogenesis Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Protein-containing Complex Assembly Positive Regulation Of Autophagosome Assembly
Pathways		Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions	Macroautophagy Regulation of TNFR1 signaling TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy
Drugs			Fostamatinib
Diseases		Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS		Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)	Body mass index ( 26426971) Mercury levels ( 26025379)
Interacting Genes		12 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 OGT PTPN2 SNW1 SYNE4 TNFAIP3 ULK1 USP40	26 interacting genes: ATG13 BECN1 C1QBP CALCOCO2 EXOC8 GABARAP GABARAPL2 KLHL20 MAPK14 MBP MEFV MTOR MUL1 NEDD4L OCLN PEDS1 POLE PPP1CA PRKAA1 RIPK2 SDCBP SMCR8 STAMBP SYNGAP1 UBC USP20
Entrez ID		100506658	8408
HPRD ID			11933
Ensembl ID		ENSG00000197822	ENSG00000177169
Uniprot IDs		A0A0G2JMZ8 A8K3T2 Q16625	O75385
PDB IDs		1WPA 1XAW 3G7C	4WNO 4WNP 5CI7 6HYO 6MNH 6QAS 8P5G 8P5H 8P5I 8P5J 8P5K 8P5L 8SOI 8SQZ 8SRM 8SV9 9C82 9F32
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Negative Regulation Of Protein-containing Complex Assembly Sin3-type Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Macroautophagy Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Cellular Response To Nutrient Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Nutrient Levels Regulation Of Signaling Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Gluconeogenesis Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Mitophagy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Detection Of Yeast Detection Of Molecule Of Fungal Origin TORC1 Signaling Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Interleukin-2 Production Positive Regulation Of TORC1 Signaling Autophagy Organelle Assembly Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion	Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Autophagy Autophagosome Macroautophagy Autophagosome Assembly Autophagosome Organization Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Vacuole Organization Intracellular Signaling Cassette Cytosol Positive Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Macroautophagy Cellular Response To Nitrogen Starvation Programmed Cell Death Cell Death Positive Regulation Of Organelle Organization Negative Regulation Of Intracellular Signal Transduction Catabolic Process Mitophagy Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-12 Production Autophagy Of Mitochondrion Regulation Of Immune Response P38MAPK Cascade Cellular Response To Starvation Cellular Response To Stress Negative Regulation Of Lysosome Organization Regulation Of Metabolic Process Regulation Of Chemokine Production Negative Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Cellular Component Organization Response To Starvation Positive Regulation Of Protein-containing Complex Disassembly Post-translational Protein Modification Negative Regulation Of Macroautophagy Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Growth Response To Mitochondrial Depolarisation Regulation Of Organelle Assembly Cellular Response To Nutrient Levels Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Xenophagy
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