SPAG5-AS1 and USP14

Number of citations of the paper that reports this interaction (PubMedID 31957155)
38

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		SPAG5-AS1	USP14
Description		SPAG5 antisense RNA 1	ubiquitin specific peptidase 14
Image		No pdb structure
GO Annotations	Cellular Component		Proteasome Complex Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Synapse Extracellular Exosome Glutamatergic Synapse Presynaptic Cytosol
	Molecular Function		Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Proteasome Binding Deubiquitinase Activity
	Biological Process		Immune System Process Proteolysis Inflammatory Response Chemical Synaptic Transmission Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Ub-specific processing proteases Regulation of NF-kappa B signaling
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		2 interacting genes: SPAG5 USP14	19 interacting genes: ATF2 CDK1 CEBPA CXCR4 FANCC ISG15 OGT PSMD2 SEM1 SGTA SPAG5-AS1 TAFAZZIN TGFBR1 TRIM11 UBC USP15 USP21 USP28 XRCC6
Entrez ID		100506436	9097
HPRD ID			06279
Ensembl ID			ENSG00000101557
Uniprot IDs			P54578
PDB IDs			2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M
Enriched GO Terms of Interacting Partners?		Proteasome Binding Presynaptic Cytosol Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway K63-linked Deubiquitinase Activity Positive Regulation Of Spindle Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Microtubule Plus-end Ciliary Rootlet Protein Localization To Centrosome Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Endopeptidase Inhibitor Activity Proteasome Complex Cysteine-type Endopeptidase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Spindle Localization Establishment Of Spindle Orientation Mitotic Sister Chromatid Segregation Protein Localization To Cytoskeleton Mitotic Spindle Pole Spindle Localization Nuclear Chromosome Segregation Regulation Of Spindle Assembly Sister Chromatid Segregation	Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Protein Modification Process Response To Stress Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Post-translational Protein Modification Nucleus Regulation Of Multicellular Organismal Development Protein-containing Complex Protein Tag Activity Cysteine-type Deubiquitinase Activity Cellular Response To Stress DNA Damage Response White Fat Cell Differentiation DNA Damage Checkpoint Signaling Cellular Response To Chemical Stress DNA Repair Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Deubiquitinase Activity Cysteine-type Peptidase Activity Regulation Of Developmental Process Negative Regulation Of Cell Cycle Cyclin Binding Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Response To Virus DNA Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Cell Population Proliferation Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Abducens Nucleus Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
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