USP14 and CXCR4

Number of citations of the paper that reports this interaction (PubMedID 19106094)
45

Data Source:
BioGRID (affinity chromatography technology, pull down)

		USP14	CXCR4
Description		ubiquitin specific peptidase 14	C-X-C motif chemokine receptor 4
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GO Annotations	Cellular Component	Proteasome Complex Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Synapse Extracellular Exosome Glutamatergic Synapse Presynaptic Cytosol	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Proteasome Binding Deubiquitinase Activity	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	Immune System Process Proteolysis Inflammatory Response Chemical Synaptic Transmission Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Response To Hypoxia Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Response To Virus Cell Migration Calcium-mediated Signaling Neurogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Cell Migration CXCL12-activated CXCR4 Signaling Pathway Myelin Maintenance Symbiont Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Ub-specific processing proteases Regulation of NF-kappa B signaling	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs		Phenethyl Isothiocyanate	Baclofen Framycetin AMD-070 Plerixafor Ulocuplumab Ibalizumab MSX-122
Diseases			Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 19525953 31604244) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: ATF2 CDK1 CEBPA CXCR4 FANCC ISG15 OGT PSMD2 SEM1 SGTA SPAG5-AS1 TAFAZZIN TGFBR1 TRIM11 UBC USP15 USP21 USP28 XRCC6	43 interacting genes: ACAT1 AGO3 ARRB2 ATP13A2 B2M CCR5 CD4 CDRT15P3 CLCN5 COL4A1 CTSG CXCL12 DHX57 DPP4 DUXAP9 ELANE FTO GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RALB RNF113A SCAMP2 SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		9097	7852
HPRD ID		06279	01217
Ensembl ID		ENSG00000101557	ENSG00000121966
Uniprot IDs		P54578	A0A0U3FJG0 A0A0U3GXA9 A0A8Q3WLL1 P61073
PDB IDs		2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS 8GP3 8I0Q 8K3Z 8U4N 8U4O 8U4P 8U4Q 8U4R 8U4S 8U4T 8YU7 8ZPL 8ZPM 8ZPN
Enriched GO Terms of Interacting Partners?		Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Protein Modification Process Response To Stress Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Post-translational Protein Modification Nucleus Regulation Of Multicellular Organismal Development Protein-containing Complex Protein Tag Activity Cysteine-type Deubiquitinase Activity Cellular Response To Stress DNA Damage Response White Fat Cell Differentiation DNA Damage Checkpoint Signaling Cellular Response To Chemical Stress DNA Repair Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Deubiquitinase Activity Cysteine-type Peptidase Activity Regulation Of Developmental Process Negative Regulation Of Cell Cycle Cyclin Binding Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Response To Virus DNA Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Cell Population Proliferation Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Abducens Nucleus Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Regulation Of Cell-cell Adhesion Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Regulation Of Defense Response Positive Regulation Of T Cell Activation Response To Stress Defense Response Positive Regulation Of Immune System Process Interleukin-9-mediated Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Response To Other Organism Cell Activation Immune System Process Negative Regulation Of Leukocyte Cell-cell Adhesion Response To External Biotic Stimulus Regulation Of Cytokine Production Interleukin-15-mediated Signaling Pathway Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Cell Migration Regulation Of Leukocyte Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Activation Leukocyte Mediated Cytotoxicity T Cell Activation Negative Regulation Of T Cell Activation Positive Regulation Of Immune Response Regulation Of Developmental Process Interleukin-6-mediated Signaling Pathway Regulation Of Multicellular Organismal Process
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