ZBTB5 and SWAP70

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ZBTB5	SWAP70
Description		zinc finger and BTB domain containing 5	switching B cell complex subunit SWAP70
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Lamellipodium
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding ATP Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Isotype Switching Regulation Of Catalytic Activity Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Mast Cell Chemotaxis Negative Regulation Of Peptidyl-serine Dephosphorylation
Pathways			RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Daytime nap ( 33568662)	Blood protein levels ( 30072576 29875488) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653 27841878 28739976 30487518) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 29403010 30487518) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 27841878 30487518 30578418) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: BAG4 CCDC85B DCX JADE2 METTL5 PPARG PTPN5 ST3GAL3 SWAP70 ZBTB7B	5 interacting genes: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5
Entrez ID		9925	23075
HPRD ID		08829	10378
Ensembl ID		ENSG00000168795	ENSG00000133789
Uniprot IDs		O15062 Q5T942	B3KUB9 E7EMB1 Q9UH65
PDB IDs			2DN6
Enriched GO Terms of Interacting Partners?
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