SWAP70 and IGHG1

Number of citations of the paper that reports this interaction (PubMedID 10681448)
17

Data Source:
HPRD (in vitro)

		SWAP70	IGHG1
Description		switching B cell complex subunit SWAP70	immunoglobulin heavy constant gamma 1 (G1m marker)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Lamellipodium	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Blood Microparticle
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding ATP Binding Cadherin Binding	Antigen Binding Protein Binding Immunoglobulin Receptor Binding
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Isotype Switching Regulation Of Catalytic Activity Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Mast Cell Chemotaxis Negative Regulation Of Peptidyl-serine Dephosphorylation	Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653 27841878 28739976 30487518) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 29403010 30487518) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 27841878 30487518 30578418) White blood cell count ( 32888494)	Blood protein levels ( 29875488) Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)
Interacting Genes		5 interacting genes: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5	7 interacting genes: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5
Entrez ID		23075	3500
HPRD ID		10378	11755
Ensembl ID		ENSG00000133789	ENSG00000211896
Uniprot IDs		B3KUB9 E7EMB1 Q9UH65
PDB IDs		2DN6
Enriched GO Terms of Interacting Partners?
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