SWAP70 and RAPGEF4

Number of citations of the paper that reports this interaction (PubMedID 24722188)
63

Data Source:
BioGRID (two hybrid)

		SWAP70	RAPGEF4
Description		switching B cell complex subunit SWAP70	Rap guanine nucleotide exchange factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Lamellipodium	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding ATP Binding Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Small GTPase Binding
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Isotype Switching Regulation Of Catalytic Activity Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Mast Cell Chemotaxis Negative Regulation Of Peptidyl-serine Dephosphorylation	Adaptive Immune Response G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Catalytic Activity Regulation Of Synaptic Vesicle Cycle
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653 27841878 28739976 30487518) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 29403010 30487518) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 32723749) Systolic blood pressure ( 27841878 30487518 30578418) White blood cell count ( 32888494)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting blood glucose ( 33842983) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		5 interacting genes: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5	13 interacting genes: ATXN1 BMERB1 DEF6 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A
Entrez ID		23075	11069
HPRD ID		10378	06929
Ensembl ID		ENSG00000133789	ENSG00000091428
Uniprot IDs		B3KUB9 E7EMB1 Q9UH65	B7Z278 Q8WZA2
PDB IDs		2DN6
Enriched GO Terms of Interacting Partners?
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