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SMG7 and GSK3A
Number of citations of the paper that reports this interaction (PubMedID
30824926
)
2
Data Source:
BioGRID
(two hybrid)
SMG7
GSK3A
Description
SMG7 nonsense mediated mRNA decay factor
glycogen synthase kinase 3 alpha
Image
GO Annotations
Cellular Component
Nucleus
Telomerase Holoenzyme Complex
Cytoplasm
Cytosol
Intermediate Filament Cytoskeleton
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Microtubule
Axon
Beta-catenin Destruction Complex
Neuronal Cell Body
Apical Dendrite
Postsynapse
Proximal Dendrite
Molecular Function
Protein Binding
Telomeric DNA Binding
Protein Phosphatase 2A Binding
Telomerase RNA Binding
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Kinase A Catalytic Subunit Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
MRNA Export From Nucleus
Regulation Of Dephosphorylation
Regulation Of Systemic Arterial Blood Pressure
Cardiac Left Ventricle Morphogenesis
Glycogen Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Protein Phosphorylation
Signal Transduction
Dopamine Receptor Signaling Pathway
Nervous System Development
Aging
Insulin Receptor Signaling Pathway
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of UDP-glucose Catabolic Process
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of TOR Signaling
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Interleukin-3
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Hypermethylation Of CpG Island
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Heart Contraction
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Excitatory Postsynaptic Potential
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Lithium Ion
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Amyloid-beta Formation
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Glycogen Synthase Activity, Transferring Glucose-1-phosphate
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Dendrite Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
Suppression of apoptosis
Maturation of nucleoprotein
Maturation of nucleoprotein
Drugs
Fostamatinib
Diseases
GWAS
Initial pursuit acceleration (
29064472
)
Systemic lupus erythematosus (
27399966
26502338
28714469
)
Meat-related diet (
32066663
)
Interacting Genes
7 interacting genes:
FGFR3
GSK3A
GSK3B
MDM2
SIRPA
SMG5
TNFSF4
80 interacting genes:
AKAP11
AKT1
ALKBH3
AP3D1
AURKAIP1
AXIN2
BCCIP
BCL2L1
BCL3
BICD1
C11orf98
CCDC174
CHTOP
CNTROB
CREB1
CREM
DCAF8
DCP1B
DDI1
DEAF1
DNAJB1
DRC1
EBNA1BP2
EIF2B5
FAM193B
FBXO42
GLI3
GOLGA6C
GSKIP
H2AZ2
HMBS
HMGN1
HNRNPM
HSF1
HSP90AA1
HSP90AB1
LDHA
LRP6
LRRC37A2
LRSAM1
MAEA
MAPT
MCL1
MPHOSPH9
MTCH1
MYC
MYL12A
NBR1
OGT
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
PRKCH
PRKCZ
PRKD3
PRKDC
PSMD8
PTMA
PXN
RICTOR
RPL15
RPL19
RPL29
RPS15
RPS19
RUNX1
SBNO1
SGK1
SGK3
SMARCA5
SMG7
SPG21
STAT2
SUGP2
TTC16
UBTF
VCPIP1
YWHAG
Entrez ID
9887
2931
HPRD ID
10723
06002
Ensembl ID
ENSG00000116698
ENSG00000105723
Uniprot IDs
E9PD50
Q6TV06
Q92540
A0A024R0L5
P49840
PDB IDs
1YA0
2DFM
Enriched GO Terms of Interacting Partners
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